The use of negative pressure therapy has been reported previously in a variety of care settings, but not in spinal cord-injured (SCI) patients. These individuals are at greatly increased risk of pressure ulcer development because of many factors associated with their neurological deficit and the incidence of pressure ulcers is high among them. This small case series employed objective measures to evaluate the effectiveness of negative pressure therapy when used to prepare pressure ulcers for surgical closure. The treated wounds demonstrated increased granulation tissue development and reduced wound colonization, and the reduced frequency of dressing changes compared with other treatment options may reduce the nursing workload. These case studies highlight the benefits of negative pressure therapy to SCI patients and emphasise the need for further work to compare the technique with other treatment options and determine the optimal application parameters of negative therapy in this patient group.
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http://dx.doi.org/10.12968/bjon.2002.11.Sup1.12247 | DOI Listing |
Sci Rep
January 2025
College of Hydraulic and Civil Engineering, Xinjiang Agricultural University, 311 East Nongda Rd, Urumqi, 830052, China.
Water conveyance channels in cold and arid regions pass through several saline-alkali soil areas. Canal water leakage exacerbates the salt expansion traits of such soil, damaging canal slope lining structures. To investigate the mechanical properties of saline clay, this study conducted indoor tests, including direct shear, compression, and permeation tests, and scanning electron microscopy (SEM) analysis of soil samples from typical sites.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Obstructive sleep apnea (OSA) patients have varying degrees of cognitive impairment, but the specific pathogenic mechanism is still unclear. Meanwhile, poor compliance with continuous positive airway pressure (CPAP) in OSA prompts better solutions. This study aimed to identify differentially expressed genes between the non-obese OSA patients and healthy controls, and to explore potential biomarkers associated with cognitive impairment.
View Article and Find Full Text PDFJ Foot Ankle Res
March 2025
Department of Orthopaedic Surgery, Akershus University Hospital, Lørenskog, Norway.
Introduction: Diabetes-related foot ulcer (DFU) is the leading cause for lower extremity amputations (LEAs) in western countries, and may cause social isolation, depression, and death. However, people with DFU are not offered the same prioritized care as cancer patients, despite comparable mortality rates. We therefore decided to create a clinical pathway for patients with DFU.
View Article and Find Full Text PDFObjective: Aim: To improve the results of treatment of patients with chronic wounds of the lower extremities by using complex treatment, including surgical interventions, VAC- therapy, as well as studying the effect of negative pressure on bacterial films of wounds, based on microbiological examination and immune-histochemical data.
Patients And Methods: Materials and Methods: During the period from 2019 to 2023 at the department's clinic, 68 patients with chronic wounds of the lower extremities were examined and treated. These are mainly women (n=63) aged from 35 to 80 years.
Phys Eng Sci Med
January 2025
School of Biological Science and Medical Engineering, Beihang University, 37 Xueyuan Road, Haidian District, Beijing, 100191, China.
Extracorporeal shock wave therapy (ESWT) achieves its therapeutic purpose mainly through the biological effects produced by the interaction of shock waves with tissues, and the accurate measurement and calculation of the mechanical parameters of shock waves in tissues are of great significance in formulating the therapeutic strategy and evaluating the therapeutic effect. This study utilizes the approach of implanting flexible polyvinylidene fluoride (PVDF) vibration sensors inside the tissue-mimicking phantom of various thicknesses to capture waveforms at different depths during the impact process in real time. Parameters including positive and negative pressure changes (P, P), pulse wave rise time ([Formula: see text]), and energy flux density (EFD) are calculated, and frequency spectrum analysis of the waveforms is conducted.
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