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Semaphorin 3A repulsion directs the caudal projection of pioneer longitudinal axons in the developing chicken brain.
Dev Biol
February 2025
School of the Environment and Life Sciences, Institute of Life Sciences and Healthcare, University of Portsmouth, Portsmouth, UK. Electronic address:
The medial longitudinal fasciculus (MLF) is the first axon tract to develop in the ventral vertebrate brain. It originates in the diencephalon and projects caudally into the spinal cord, pioneering the path for later developing axons. Previous anatomical and expression analyses in the chicken suggested Semaphorin 3 A (Sema3A) as the candidate to repel the amniote MLF from the forebrain.
View Article and Find Full Text PDFSARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia.
Int J Mol Sci
July 2024
Center for Emerging Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute & State University, Blacksburg, VA 24060, USA.
Neurological symptoms associated with COVID-19, acute and long term, suggest SARS-CoV-2 affects both the peripheral and central nervous systems (PNS/CNS). Although studies have shown olfactory and hematogenous invasion into the CNS, coinciding with neuroinflammation, little attention has been paid to susceptibility of the PNS to infection or to its contribution to CNS invasion. Here we show that sensory and autonomic neurons in the PNS are susceptible to productive infection with SARS-CoV-2 and outline physiological and molecular mechanisms mediating neuroinvasion.
View Article and Find Full Text PDFIdentification of z-axis filopodia in growth cones using super-resolution microscopy.
J Neurochem
September 2024
Department of Neurochemistry and Molecular Cell Biology, School of Medicine, and Graduate School of Medical/Dental Sciences, Niigata University, Niigata, Japan.
A growth cone is a highly motile tip of an extending axon that is crucial for neural network formation. Three-dimensional-structured illumination microscopy, a type of super-resolution light microscopy with a resolution that overcomes the optical diffraction limitation (ca. 200 nm) of conventional light microscopy, is well suited for studying the molecular dynamics of intracellular events.
View Article and Find Full Text PDFNeuropilin invites reoviruses into neurons.
Cell Host Microbe
June 2024
Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA. Electronic address:
In this issue of Cell Host & Microbe, Shang et al. identify murine neuropilin 1 as a host factor that binds reovirus particles, directing cell entry and contributing to viral dissemination and neurovirulence. This study highlights the reovirus model system to investigate host receptors and their significance in viral pathogenesis.
View Article and Find Full Text PDFNRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits.
Cell Host Microbe
June 2024
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:
Mammalian orthoreovirus (reovirus) is a nonenveloped virus that establishes primary infection in the intestine and disseminates to sites of secondary infection, including the CNS. Reovirus entry involves multiple engagement factors, but how the virus disseminates systemically and targets neurons remains unclear. In this study, we identified murine neuropilin 1 (mNRP1) as a receptor for reovirus.
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