From the stem bark of Millettia erythrocalyx, three new compounds, namely, millettocalyxins A-C (1-3), and the new natural product pongol methyl ether (4) were isolated, along with 10 other known compounds. The structures of the new isolates were elucidated on the basis of spectroscopic data interpretation.
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http://dx.doi.org/10.1021/np010513z | DOI Listing |
Pharmaceuticals (Basel)
October 2021
Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Unlabelled: Cancer stem cells (CSCs) are an important therapeutic target. The therapeutic agents targeting CSCs should lead to improved clinical outcomes. Here we have demonstrated the CSC-suppressing activity of pongol methyl ether (PME), a pure compound from .
View Article and Find Full Text PDFAnticancer Res
August 2021
Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
Background/aim: Integrin-targeting compounds have shown clinically significant benefits in many patients. Here, we examined the activity of millettocalyxin B, extracted from the stem bark of Millettia erythrocalyx, in lung cancer cells.
Materials And Methods: The viability of human lung cancer cells was investigated by the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyl tetrazoliumbromide (MTT) assay.
Phytochemistry
April 2006
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
From the pods of Millettia erythrocalyx, 2'-hydroxy-3,4-dimethoxy-[2'',3'':4',3']-furanochalcone, 2',3-dihydroxy-4-methoxy-4'-gamma,gamma-dimethylallyloxychalcone, (-)-(2S)-6,3',4'-trimethoxy-[2'',3'':7,8]-furanoflavanone, 3',4'-methylenedioxy-[2'',3'':7,8]-furanoflavonol and 6,3'-dimethoxy-[2'',3'':7,8]-furanoflavone were isolated, along with six other known flavonoids. Their structures were elucidated through analysis of their spectroscopic data.
View Article and Find Full Text PDFNat Prod Res
February 2005
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
From the leaves of Millettia erythrocalyx, a new flavone named 3',5'-dimethoxy-[2",3": 7,8]-furanoflavone and three known compounds were isolated. Assays for anti-herpes simplex virus activity (HSV-1 and HSV-2) were performed on 24 phenolic compounds obtained from M. erythrocalyx and Artocarpus lakoocha.
View Article and Find Full Text PDFPhytochemistry
December 2002
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
From the roots of Millettia erythrocalyx, 6-methoxy-[2",3":7,8]-furanoflavanone, 2,5-dimethoxy-4-hydroxy-[2",3":7,8]-furanoflavan, and 3,4-methylenedioxy-2',4'-dimethoxychalcone were isolated, along with ten other known flavonoids. Their structures were elucidated on the basis of analyses of their spectroscopic data.
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