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Impact of deep or ovarian endometriosis on pelvic pain and quality of life: prospective cross-sectional ultrasound study.
Ultrasound Obstet Gynecol
January 2025
EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London Hospital, London, UK.
Objective: To assess whether premenopausal women diagnosed with deep or ovarian endometriosis on transvaginal sonography (TVS) were more likely to suffer from dyspareunia and pelvic pain symptoms, and have a lower quality of life, compared to women without sonographically diagnosed deep or ovarian endometriosis.
Methods: This was a prospective, cross-sectional study carried out between February 2019 and October 2020 at the general gynecology clinic at University College London Hospital, London, UK. All premenopausal women aged 18-50 years, who were examined consecutively by a single experienced examiner and underwent a detailed TVS scan, were eligible for inclusion.
[Online phenotypes of depression symptoms are associated with polygenic risk scores of somatic diseases in a population-based cohort].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russia.
Objective: To test an associations of online phenotypes of depressive symptoms with polygenic risk scores (PRS) for selected somatic diseases in a population-based cohort.
Material And Methods: Participants in a Russian population-based cohort (=4520) underwent online phenotyping based on the originally developed questionnaire using DSM-5 criteria (DSM phenotypes) and the Hospital Anxiety and Depression Scale (HADS) questionnaire (HADS phenotypes). After DNA genotyping with microarrays, PRS were calculated using summary statistics from large-scale GWASs (mostly from UK Biobank) for irritable bowel syndrome (IBS), coronary heart disease (narrow and broad phenotypes) (CHD), ischemic stroke (IS),diabetes mellitus type 2 (DT2) and migraine (MG).
Shared Genetics of Migraine and Gastrointestinal Disorders Implicates Underlying Neurologic Mechanisms Yet Heterogeneous Etiologies.
Neurol Genet
December 2024
From the Division of Preventive Medicine (D.I.C., Y.G., P.M.R.), Brigham and Women's Hospital and Harvard Medical School; and the Clinical and Translational Epidemiology Unit (A.T.C., K.S.) and Division of Gastroenterology (A.T.C., K.S.), Massachusetts General Hospital, and Harvard Medical School, Boston, MA.
Background And Objectives: Migraine is strongly comorbid with irritable bowel syndrome (IBS), one of several gastrointestinal (GI) conditions that are distinguished by symptomatic profiles that are partly overlapping. Potential shared mechanisms of migraine and the GI conditions were investigated by assessing shared genetics on a genome-wide basis.
Methods: Analyses leveraged genome-wide summary statistics from large-scale genetic studies for migraine, including by aura status, IBS, peptic ulcer disease (PUD), gastrointestinal reflux (GERD), functional dyspepsia (FD), diverticular disease (DD), and the immune-related inflammatory bowel disease (IBD) or its constituents, ulcerative colitis (UC) and Crohn disease (CD).
Full moon mesencephalon sign: a transient cytotoxic lesion in a hemodialysis patient with newly diagnosed atrial fibrillation and severe stenosis of the right vertebral artery.
Neurol Sci
December 2024
Department of Neurology, Martin Gropius Hospital, Eberswalde, Germany.
Brain cytotoxic edema is a neuroradiological sign secondary to variegate diseases ranging from migraine to fulminant Listeria rhombencephalitis. The tempestive identification of its underlying cause is vital for an effective treatment as any delay may be fatal. However, the lack of distinctive imaging biomarkers and the paucity of reports pose a significant challenge in its diagnosis and frequently lead to a misdiagnosis particularly with the more common acute ischemic stroke.
View Article and Find Full Text PDFHeadache disorders in patients with Ehlers-Danlos syndromes and hypermobility spectrum disorders.
Front Neurol
November 2024
Headache and Facial Pain Group, University College London (UCL), Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Extra-articular symptoms, including headaches, are frequently encountered in patients with Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders (HSD), and may be the presenting complaint. Migraine is reported in up to three quarters of patients with symptomatic joint hypermobility, have a higher headache frequency, and an earlier age of onset compared to the general population. Orthostatic headache is an important presentation, and should raise suspicion of an underlying spinal cerebrospinal fluid leak, dysautonomia, and craniocervical pathology, which are all associated with heritable connective tissue disorders (HCTD) including EDS.
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