[Genetically engineered mice and its application to bioindustry].

More than 2 decades have past since the first transgenic mouse was created. In this review we will focus on recent technologies in the field of mouse genetic engineering and on its application to bioindustry. The most important milestone in this field was the invention of the gene targeting technique. Recent improvement of this technique to conditional gene targeting together with the Cre/IoxP system further encouraged the generation of mutant mice. It is obvious that there will be a great demand for some mutant mice as experimental models of human disease or as resources of experimental material for basis biological research. Thus, creation of such mice would be a rewarding challenge for a biological enterprise.