AI Article Synopsis
- A mathematical model simulates how cell populations behave in a tumor cord structure, which is a cylindrical arrangement of tumor cells around a blood vessel and surrounded by dead tissue.
- The model includes factors like cell migration from the inner to outer zones and incorporates different stages of the cell cycle, allowing for variations in how cells progress through these stages.
- Results from the model are compared with experimental data, revealing that cell migrations significantly affect the evaluation of how quickly cells progress through the cycle as you move from the center to the edges of the tumor cord.
Article Abstract
A mathematical model is developed that describes the proliferative behaviour at the stationary state of the cell population within a tumour cord, i.e. in a cylindrical arrangement of tumour cells growing around a blood vessel and surrounded by necrosis. The model, that represents the tumour cord as a continuum, accounts for the migration of cells from the inner to the outer zone of the cord and describes the cell cycle by a sequence of maturity compartments plus a possible quiescent compartment. Cell-to-cell variability of cycle phase transit times and changes in the cell kinetic parameters within the cord, related to changes of the microenvironment, can be represented in the model. The theoretical predictions are compared against literature data of the time course of the labelling index and of the fraction of labelled mitoses in an experimental tumour after pulse labelling with 3H-thymidine. It is shown that the presence of cell migration within the cord can lead to a marked underestimation of the actual changes along cord radius of the kinetics of cell cycle progression.
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| http://dx.doi.org/10.1016/s0025-5564(01)00114-6 | DOI Listing |
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