The continuously increasing demand for biomolecules, e.g. human proteins, for applications in human health care, is one of the main driving forces for the development of safe, large-scale production systems. One very promising approach is the production of biomolecules in the milk of transgenic cattle. By using nuclear transfer technology, transgenic cattle can be generated in a very safe and efficient manner, thereby offering a significant time reduction when compared to conventional breeding methods. As a result, that the transgenic cattle platform offers an efficient, safe and cost-effective method for producing large amounts of biopharmaceuticals, which is essential to the development of innovative health care products.
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Front Genome Ed
January 2025
Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Protein drug production encompasses various methods, among which animal bioreactors are emerging as a transgenic system. Animal bioreactors have the potential to reduce production costs and increase efficiency, thereby producing recombinant proteins that are crucial for therapeutic applications. Various species, including goats, cattle, rabbits, and poultry, have been genetically engineered to serve as bioreactors.
View Article and Find Full Text PDFAnimals (Basel)
January 2025
State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (R2BGL), Inner Mongolia University, 24 Zhaojun Rd., Hohhot 010070, China.
Polyunsaturated fatty acids (PUFAs) such as linoleic acid (18:2, n-6) and α-linolenic acid (18:3, n-3) are essential for the growth, development, and well-being of mammals. However, most mammals, including humans, cannot synthesize n-3 and n-6 PUFAs and these must be obtained through diet. The beneficial effect of converting n-6 polyunsaturated fatty acids (n-6 PUFAs) into n-3 polyunsaturated fatty acids (n-3 PUFAs) has led to extensive research on the flax fatty acid desaturase 3 () gene, which encodes fatty acid desaturase.
View Article and Find Full Text PDFCells
December 2024
Department of Obstetrics and Gynecology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0617, USA.
Classical preimplantation embryo culture is performed in static fluid environments. Whether a dynamic fluid environment, like the fallopian tube, is beneficial for embryo development remains to be determined across mammalian species. Objectives of these proof-of-concept studies were to determine if controllable dynamic microfluidic culture would enhance preimplantation murine, bovine, and human embryo development compared to static culture.
View Article and Find Full Text PDFJDS Commun
November 2024
Department of Preventive Veterinary Medicine and Animal Reproduction, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, 14884-900, Brazil.
Genome editing is the latest breeding tool capable of accelerating the rate of genetic improvement for health and well-being traits in food animals. It enables the introduction of beneficial alleles within a single generation, including those that are of low frequency or absent in the population, while effectively bypassing linkage drag. For the dairy industry, genome editing can be used to make rapid genetic improvements that are precise, efficient, and transgene-free for functional traits that are not practically addressed without disrupting conventional breeding goals for overall economic merit based on genomic selection.
View Article and Find Full Text PDFParasit Vectors
October 2024
State Key Laboratory for Animal Disease Control and Prevention Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
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