AI Article Synopsis
- The UL53 gene of human cytomegalovirus (HCMV) encodes a new structural protein, pUL53, whose expression and localization were studied.
- pUL53 is found in the cytoplasm of infected human fibroblasts as well as at the nuclear periphery, where it interacts with lamin B, indicating its structural role in the virus.
- The research suggests pUL53 may play a key role in the maturation of nucleocapsids or their transport from the nucleus to the cytoplasm, similar to the function of the UL31 protein in herpes simplex virus type 1.
Article Abstract
Human cytomegalovirus (HCMV) UL53 belongs to a family of conserved herpesvirus genes. In this work, the expression and localization of the UL53 gene product was analysed. Results obtained showed that pUL53 is a new structural protein. In infected human fibroblasts, pUL53 localizes in cytoplasmic perinuclear granular formations together with other structural viral proteins. In the nucleus, pUL53 forms patches at the nuclear periphery and co-localizes with lamin B at the internal nuclear membrane level. Immunoelectron microscopy studies have disclosed that nuclear pseudo-inclusions are labelled, whereas nucleocapsid formations within the intranuclear skein are negative. Furthermore, the mature virus particle maintains pUL53 at its tegumental level. These data suggest that pUL53 could be involved either in nucleocapsid maturation or in the egress of nucleocapsids from the nucleus to the cytoplasm through the nuclear membrane, a role compatible with the function hypothesized for UL31, its positional homologue in herpes simplex virus type 1.
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| http://dx.doi.org/10.1099/0022-1317-83-5-1005 | DOI Listing |
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