Synthesis and immunofluorescence assay of a new biotinylated paclitaxel.

Eur J Med Chem

Department of Chemistry, Organosilicon and Synthesis Laboratory, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.

Published: April 2002

7-(5'-Biotinylamidopropanoyl)paclitaxel was synthesised by chemical methods; its immunofluorescence assay and the cell uptake experiments were performed by use of human leukemia U937 cells. The results indicate that paclitaxel is arresting cell cycle at the G(2)M phase only.

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http://dx.doi.org/10.1016/s0223-5234(02)01337-5DOI Listing

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