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Optimal direct oral anticoagulant for upper gastrointestinal endoscopic submucosal dissection.
J Gastroenterol
January 2025
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, 980-8574, Japan.
Background: The patients taking direct oral anticoagulants (DOACs) are at high risk for developing ischemic stroke and delayed bleeding in upper gastrointestinal endoscopic submucosal dissection (ESD). We aimed to identify the optimal DOAC based on both adverse events in upper gastrointestinal ESD.
Methods: A retrospective population-based cohort study was conducted using the Diagnosis Procedure Combination database in Japan.
Investigation of the effects of a new transdermal formulation of systemic diclofenac on the upper gastrointestinal mucosa in patients with low back pain: A comparative study with oral diclofenac.
J Gastroenterol Hepatol
December 2024
Hisamitsu Pharmaceutical Co., Inc., Tokyo, Japan.
Article Synopsis
- - This study examines the gastrointestinal safety of diclofenac sodium when administered via a transdermal patch (DSSP) versus an oral tablet (DST) in patients with low back pain (LBP).
- - Results showed that DSSP significantly reduced the incidence of gastroduodenal ulcers and erosions (26.7%) compared to DST (86.2%), demonstrating a -59.5% difference in risk.
- - Additionally, no adverse events were reported with DSSP, while 20% of patients using DST experienced mild adverse effects, highlighting DSSP's safety advantage.
Amino acid deletions at positions 893 and 894 of cytotoxin-associated gene A protein affect gastric epithelial cell interactions.
World J Gastroenterol
November 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Background: () persistently colonizes the human gastric mucosa in more than 50% of the global population, leading to various gastroduodenal diseases ranging from chronic gastritis to gastric carcinoma. Cytotoxin-associated gene A (CagA) protein, an important oncoprotein, has highly polymorphic Glu-Pro-Ile-Tyr-Ala segments at the carboxyl terminus, which play crucial roles in pathogenesis. Our previous study revealed a significant association between amino acid deletions at positions 893 and 894 and gastric cancer.
View Article and Find Full Text PDFAssociation of infection and white blood cell count: a cross-sectional study.
BMJ Open
November 2024
Department of Gastroenterology, Shenmu Hospital, The Affiliated Hospital of Northwest University. Faculty of Life Sciences and Medicine, Northwest University, Guangming Road, Shenmu, China
Article Synopsis
- This study investigates the relationship between the presence of Gram-negative bacteria, specifically Helicobacter pylori (Hp), and white blood cell (WBC) counts in individuals undergoing physical exams, noting that Hp can lead to digestive issues like gastritis and ulcers.* ! -
- Data from 864 participants showed that those infected with Hp had significantly higher WBC counts compared to those without the infection, suggesting a possible link between Hp infection and immune response.* ! -
- Statistical analyses revealed a positive correlation between the number of Hp bacteria (measured through a breath test) and WBC counts, indicating that higher infection levels may lead to increased WBC counts in the body.* !
Association between prophylactic closure of mucosal defect and delayed adverse events after endoscopic resection: a systematic review and meta-analysis.
BMJ Open
October 2024
Digestive Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
Article Synopsis
- The study aims to assess whether closing mucosal defects can prevent complications after endoscopic resection of the GI wall.
- A systematic review and meta-analysis of 28 studies involving 11,383 patients found that prophylactic closure significantly reduced delayed bleeding and delayed perforation events.
- However, there was no significant impact on the incidence of postpolypectomy coagulation syndrome (PPCS) from the closure method.
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