AI Article Synopsis
- The study involved 56 pediatric patients receiving azithromycin at doses of 10 or 20 mg per kg for 3 days.
- The researchers measured azithromycin levels in both plasma and tonsils up to 8.5 days after treatment.
- The findings indicated that the higher 20-mg/kg dose led to better distribution of the drug in the tonsils, which may improve treatment effectiveness for upper respiratory infections.
Article Abstract
Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127138 | PMC |
| http://dx.doi.org/10.1128/AAC.46.5.1594-1596.2002 | DOI Listing |
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