The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination half-life of piperacillin was 4.3 +/- 1.2 h, and that of tazobactam was 5.6 +/- 1.3 h. The contribution of CVVHD to the overall elimination was relevant (>25%) for both drugs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127124 | PMC |
| http://dx.doi.org/10.1128/AAC.46.5.1557-1560.2002 | DOI Listing |
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