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NF-κB signaling is the major inflammatory pathway for inducing insulin resistance.
3 Biotech
February 2025
CSIR Institute of Genomics & Integrative Biology, Sukhdev Vihar, New Delhi, 110025 India.
Unlabelled: Insulin resistance is major factor in the development of metabolic syndrome and type 2 diabetes (T2D). We extracted 430 genes from literature associated with both insulin resistance and inflammation. The highly significant pathways were Toll-like receptor signaling, PI3K-Akt signaling, cytokine-cytokine receptor interaction, pathways in cancer, TNF signaling, and NF-kappa B signaling.
View Article and Find Full Text PDFEnhancing metabolic and inflammatory status in insulin-resistant rats: Acute intervention with cocoa flavanols and submaximal aerobic exercise activates intracellular signaling pathways for glucose metabolism.
Clin Nutr
January 2025
Federal University of Minas Gerais, Department of Physical Education, Exercise Physiology Laboratory, Av. Pres. Antônio Carlos, 6627 Campus-Pampulha, Belo Horizonte, Brazil. Electronic address:
Introduction: Type 2 diabetes, characterized by hyperglycemia, is closely linked to obesity and low-grade inflammation. Acute cocoa flavanols (CF) intake has demonstrated benefits in vasoreactivity, cognitive functions, and antioxidant enzyme activity. However, the physiological mechanisms of CF concerning glucose uptake, inflammatory mediators, and their interplay with aerobic exercise remain unclear in populations with metabolic diseases.
View Article and Find Full Text PDFImproving Image Quality and Visualization of Hepatocellular Carcinoma in Arterial Phase Imaging Using Contrast Enhancement-Boost Technique.
J Comput Assist Tomogr
November 2024
From the Department of Radiology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Objective: This study aimed to evaluate the image quality and visualization of hepatocellular carcinoma (HCC) on arterial phase computed tomography (CT) using the contrast enhancement (CE)-boost technique.
Methods: This retrospective study included 527 consecutive patients who underwent dynamic liver CT between June 2021 and February 2022. Quantitative and qualitative image analyses were performed on 486 patients after excluding 41 patients.
Cancer incidence and survival for 11 cancers in the Commonwealth: a simulation-based modelling study.
Lancet Oncol
September 2024
Department of Health Policy and Management, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA; Department of Global Health and Population, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA; Department of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA, USA; Faculty of Medicine, Imperial College London, London, UK.
Background: The number of new cancer cases in Commonwealth countries rose by 35% between 2008 and 2018, but progress in cancer control has been slow in many low-income and lower-middle-income member states. We aimed to examine cancer outcomes and priority areas in the Commonwealth to provide insight and guidance on prioritisation of efforts to improve cancer survival and make the best use of scarce resources.
Methods: We adapted a previously developed microsimulation model of global cancer survival for 11 cancer sites (oesophagus, stomach, colon, rectum, anus, liver, pancreas, lung, breast, cervix uteri, and prostate).
Amelioration of airway and GI disease in G551D-CF ferrets by AAV1 and AAV6.
Gene Ther
September 2024
Departments of Physiology and Medicine, Johns Hopkins University, Baltimore, MD, USA.
Gene therapy for CF has concentrated on targeting the lung. Here we took a different approach by injecting into the cephalic vein and spraying into the trachea of G551D, CF ferrets either AAV1 or 6 containing Δ27-264-CFTR, a truncated version of CFTR. Treatment with the potentiator VX-770 was halted for 7 days before instillation to induce a disease phenotype.
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