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Galanin-like peptide stimulates food intake in the rat. | LitMetric
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Galanin-like peptide stimulates food intake in the rat.

Yoshio Matsumoto Takuya Watanabe Yuka Adachi Takashi Itoh Tetsuya Ohtaki Haruo Onda Tsutomu Kurokawa Osamu Nishimura Masahiko Fujino

Neurosci Lett

Pharmaceutical Research Division, Takeda Chemical Industries Ltd., Jusohonmachi 2-17-85, Yodogawa, Osaka, 532-8686, Japan.

Published: March 2002

We have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for galanin receptor subtype GalR2. To investigate the physiological role of GALP, we examined the effect of the intracerebroventricular administration of GALP and found that GALP induced food intakes. GALP had ten-fold the orexigenic activity of galanin. We also observed the anxiogenic-like behavior after the administration of 1 nmol GALP. These results suggest that GALP is a novel orexigenic and anxiogenic peptide.

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http://dx.doi.org/10.1016/s0304-3940(01)02515-0DOI Listing

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