AI Article Synopsis
- This study examined the relationship between angiogenic features, ATP-ase activities, and SOD concentration in patients with intracranial meningiomas and glial tumors.
- The research involved 20 tumor samples divided into two groups: 10 from meningiomas and 10 from glial tumors, revealing higher ATP-ase activities in the meningioma group but lower SOD activity compared to glial tumors.
- Electron microscopy showed more significant vascular endothelial proliferation and cytoplasmic changes in glial tumors, indicating a relationship between endothelial growth, ATP-ase levels, and SOD activity in both tumor types.
Article Abstract
The purpose of this study was to investigate the relationship among ultrastructural angiogenic features, adenosine-5'-triphosphatase (ATP-ase) activities and superoxide dismutase (SOD) concentration in the microvasculature of intracranial meningiomas and glial tumors. We examined 20 tumor materials from 20 adult patients with intracranial meningioma or glial tumor who underwent selective surgery, dividing them into two groups based on the type of the tumors. Group I consisted of 10 meningioma-materials, and Group II of 10 glial tumor-materials. Na+-K+, Mg+2 and Ca+2 ATP-ase activities in Group I were significantly higher than those in Group II (p < 0.01). The SOD activity in Group I was significantly lower than that in Group II (p < 0.01). According to electron microscopic findings, vascular endothelial proliferation and ultrastructural cytoplasmic changes in the glial tumors were more prominent than those in the meningiomas. Our results show that there is a meaningful correlation among an increased endothelial proliferation, a decreased ATP-ase level and an increased SOD activity in the meningiomas and glial tumors.
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| http://dx.doi.org/10.1179/016164102101199756 | DOI Listing |
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