When a compound cue AT is followed by an outcome (AT+), human participants will judge the relation between cue T and the outcome to be less strong if A alone was previously paired with the outcome (A+). According to the probabilistic contrast model, such a blocking effect is due to the fact that participants regard the A+ trials as trials on which A and the outcome are present but T is absent. The results of two studies showed that when the status of T was ambiguous during the A+ trials, judgments about T depended on subsequent information about the presence of T during the A+ trials. These findings support the probabilistic contrast model but are incompatible with the (revised) Rescorla-Wagner (Rescorla & Wagner, 1972) model.
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http://dx.doi.org/10.3758/bf03195262 | DOI Listing |
Aim: Chronic cocaine use is associated with decreases in neuroactive steroid levels. These adaptations may contribute to continued cocaine use and high relapse risk in individuals with cocaine use disorder (CUD). Thus, this pilot study assessed chronic treatment with 2 supraphysiologic doses of the neuroactive steroid precursor pregnenolone (PREG, 300 mg/day; 500 mg/day) to boost endogenous neuroactive steroid levels and assess its impact on provoked craving and cocaine use outcomes in an 8-week trial in men and women with CUD.
View Article and Find Full Text PDFbioRxiv
January 2025
National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.
Learning in dynamic environments requires animals to not only associate cues with outcomes but also to determine cue salience, which modulates how quickly related associations are updated. While dopamine (DA) in the nucleus accumbens core (NAcc) has been implicated in learning associations, the mechanisms of salience are less understood. Here, we tested the hypothesis that acetylcholine (ACh) in the NAcc encodes cue salience.
View Article and Find Full Text PDFAlcohol Alcohol
January 2025
Division of Treatment and Recovery, National Institute on Alcohol Abuse and Alcoholism, 6700 B Rockledge Drive, Bethesda, MD 20892, United States.
Aims: We evaluated the safety, efficacy, and patient adherence to oral ANS-6637, a selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2), for treating alcohol use disorder (AUD).
Methods: A 3-arm, double-blind, randomized, proof-of-concept human laboratory study embedded in a 5-week multisite clinical trial tested 200 mg and 600 mg daily doses of ANS-6637 compared to placebo in treatment-seeking adults with AUD. After 1 week of medication, participants completed an alcohol cue reactivity session.
Cognition
January 2025
Institute of Systems and Information Engineering, University of Tsukuba, Ibaraki 305-8573, Japan. Electronic address:
Pain perception is not solely determined by noxious stimuli, but also varies due to other factors, such as beliefs about pain and its uncertainty. A widely accepted theory posits that the brain integrates prediction of pain with noxious stimuli, to estimate pain intensity. This theory assumes that the estimated pain value is adjusted to minimize surprise, mathematically defined as errors between predictions and outcomes.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut.
Importance: Opioid use disorder (OUD) impacts millions of people worldwide. Prior studies investigating its underpinning neural mechanisms have not often considered how brain signals evolve over time, so it remains unclear whether brain dynamics are altered in OUD and have subsequent behavioral implications.
Objective: To characterize brain dynamic alterations and their association with cognitive control in individuals with OUD.
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