Pulmonary blastoma (PB) is a rare malignant tumor of the lung. Treatment is primarily surgical, although, combination chemotherapy has been reported to result in objective responses in inoperable tumors or after incomplete resections. To our knowledge, this is the first report of a very radiosensitive PB, which showed major tumor reduction after several fractions of radiotherapy without further tumor regression after additional chemotherapy with cisplatin and etoposide. The literature on the treatment of PB is reviewed.
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- The pleuropulmonary blastoma was found to have significant DICER1 mutations and other gene variants, while the unclassified tumor exhibited a specific genetic translocation leading to a YAP1::LEUTX fusion, which has associations with cancer development.
- This research emphasizes the value of whole-genome analysis in identifying the biological characteristics and potential treatment targets for rare tumors.
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