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Reduced monocyte proportions and responsiveness in convalescent COVID-19 patients.
Front Immunol
January 2024
ARUP Laboratories Institute for Clinical and Experimental Pathology, Salt Lake City, UT, United States.
Introduction: The clinical manifestations of acute severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) suggest a dysregulation of the host immune response that leads to inflammation, thrombosis, and organ dysfunction. It is less clear whether these dysregulated processes persist during the convalescent phase of disease or during long COVID. We sought to examine the effects of SARS-CoV-2 infection on the proportions of classical, intermediate, and nonclassical monocytes, their activation status, and their functional properties in convalescent COVID-19 patients.
View Article and Find Full Text PDFLinguistic meanings in mind.
Behav Brain Sci
September 2023
Department of Linguistics, University of California, Los Angeles, Los Angeles, CA, https://timhunter.humspace.ucla.edu/.
The target article focuses on evidence from nonlinguistic faculties to defend the claim that cognition generally traffics in language-of-thought (LoT)-type representations. This focus creates needed space to discuss the mounting accumulation of nonclassical evidence for LoT, but it also misses relevant work in linguistics that directly offers a perspective on specific hypotheses about candidate LoT representations.
View Article and Find Full Text PDFDefective recognition of a nonclassical nuclear localization signal in neurodevelopmental disorders.
Structure
August 2023
Department of Pharmaceutical Sciences, International University of Health and Welfare, Tochigi 324-8501, Japan. Electronic address:
In this issue of Structure, Gonzalez et al. present the cryo-EM structure of Karyopherin-β2 bound to the proline-tyrosine nuclear localization signal (PY-NLS) of heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2). The structure advances our understanding of not only the diversity of PY-NLSs but also the pathogenic mechanisms arising from HNRNPH2 variants.
View Article and Find Full Text PDFNonclassic paradigm shift: Does anyone care?
Fertil Steril
August 2022
Atrium Health Carolinas Medical Center, Charlotte, North Carolina.
6-Sulfo LacNAc monocytes are quantitatively and functionally disturbed in systemic sclerosis patients.
Clin Exp Immunol
August 2022
Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), Paris, France.
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis, microangiopathy, and autoantibodies. We previously reported that circulating follicular helper T (cTfh) cells are increased in SSc and induce plasmablast differentiation. However, mechanisms leading to cTfh cell expansion and activation in SSc remain to be established.
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