Pruritus is an essential feature of atopic dermatitis (AD) and the diagnosis of active AD cannot be made without the history of itching. Because of the high impact on life quality, most of the patients measure the severity of eczema by the intensity of pruritus rather than appearance of skin lesions. However, although pruritus is a cardinal symptom of AD, its mechanism and association with the cutaneous nervous system is not completely understood. Recently, a considerable progress has been achieved in clarifying the complex pathophysiology of pruritus in AD. As a cutaneous sensory perception, itch requires excitation of neuropeptide-containing free nerve endings of unmyelinated nociceptor fibers. It is well known that histamine and acetylcholine provoke itch by direct binding to 'itch receptors' and several mediators such as neuropeptides, proteases or cytokines indirectly via histamine release. Interestingly, some variations of these complex mechanisms could be demonstrated in patients with AD. This review highlights the recent knowledge of different mechanisms which may be involved in regulating pruritus in patients with AD potentially leading to new therapeutic applications for the treatment of itch in AD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1034/j.1600-0625.2002.110102.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterisation and Profiling of Standard Atopic Dermatitis Therapies in a Chronic Dermatitis Murine Model Induced by Oxazolone.
Exp Dermatol
December 2024
Almirall R+D Centre, Almirall S.A, Sant Feliu de Llobregat, Spain.
Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by hypersensitivity to allergens, eczematous lesions and pruritus. The aim of this study was to comprehensively characterise a murine model of dermatitis and assess the similarity with the human disease, as well as to profile clinically relevant AD therapies. Four repeated topical administrations of oxazolone in the auricular skin of sensitised mice induced morphological features compatible with AD, including redness and swelling, as well as histological changes typical of spongiotic (eczematous) dermatitis and increased plasmatic IgE.
View Article and Find Full Text PDFEffect of aromatherapy on pruritus in people receiving hemodialysis treatment: Systematic review.
J Tissue Viability
December 2024
Mersin University, Faculty of Nursing, Department of Medical Nursing, Mersin, Turkey. Electronic address:
Background: Lack of a complete understanding of the pathophysiology of pruritus directs patients to different treatments. There is little data on the effect of aromatherapy on itching in patients receiving hemodialysis treatment. However, the effect of aromatherapy on pruritus in patients receiving hemodialysis treatment remains unclear.
View Article and Find Full Text PDFAn excitatory neural circuit for descending inhibition of itch processing.
Cell Rep
December 2024
Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China. Electronic address:
Itch serves as a self-protection mechanism against harmful external agents, whereas uncontrolled and persistent itch severely influences the quality of life of patients and aggravates their diseases. Unfortunately, the existing treatments are largely ineffective. The current difficulty in treatment may be closely related to the fact that the central neural mechanisms underlying itch processing, especially descending inhibition of itch, are poorly understood.
View Article and Find Full Text PDFAtopic Dermatitis: A Review of Diagnosis and Treatment.
J Pediatr Pharmacol Ther
December 2024
Department of Pulmonary & Critical Care, Allergy and Immunology Division, Case Western Reserve University/University Hospitals Cleveland Medical Center Program, Cleveland, OH.
Article Synopsis
- Atopic dermatitis, or atopic eczema, is a chronic skin condition marked by dry skin, redness, and severe itching, with symptoms varying by age.
- It is one of the most widespread skin disorders worldwide, creating significant health and economic challenges for patients.
- Recent research into genetic, immunologic, and environmental factors has led to new treatment options, with the article detailing the condition's presentation, causes, diagnosis, and current treatment recommendations.
Bulevirtide Monotherapy Is Safe and Well Tolerated in Chronic Hepatitis Delta: An Integrated Safety Analysis of Bulevirtide Clinical Trials at Week 48.
Liver Int
December 2024
Clinic for Gastroenterology, Hepatology, Infectious Diseases, and Endocrinology, Hannover Medical School, Hannover, Germany.
Article Synopsis
- The study assessed the safety and tolerability of bulevirtide (BLV), a new treatment for chronic hepatitis delta (CHD), by analyzing data from three clinical trials involving 269 patients.
- The findings indicated that certain adverse events, such as increased bile acid levels and injection-site reactions, were more common with BLV compared to a control group, but serious side effects were minimal and did not lead to treatment discontinuation.
- Overall, BLV was deemed safe and well tolerated over 48 weeks of therapy in patients with CHD, showing promise as an effective treatment option.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!