High density porous polyethylene (HDPP) has been used extensively for craniofacial reconstructive procedures. The authors recently reviewed the records of 21 patients who had undergone correction of late (more than 6 months) posttraumatic enophthalmos utilizing HDPP implants to restore orbital integrity and volume. Follow-up after implant placement was 6 months to 54 months (mean 20 months). Twenty of 21 patients demonstrated a clinically significant reduction in enophthalmos to within 2 mm of the opposite globe, as demonstrated by Hertel and/or Naugle exophthalmometry and by clinical observation. There were no cases of worsened visual acuity, lid position or ocular mobility, and no HDPP implant became infected or was extruded. The authors' experience supports the safety and efficacy of HDPP implants for correction of mild to moderate posttraumatic enophthalmos.
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Mucosal Immunol
January 2025
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh Medical Center Pittsburgh PA USA; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine New Haven CT USA. Electronic address:
Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the sensing of tissue injury by the host shapes the anti-pathogen response remains poorly understood.
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January 2025
Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Aims: This retrospective cohort study aimed to investigate the efficacy of dual-chamber left Bundle branch pacing (LBBP) as an alternative therapy for heart failure patients with complete left bundle branch block (CLBBB) and indications for defibrillator with cardiac resynchronization therapy (CRT-D).
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Br J Ophthalmol
January 2025
Ocular Oncology Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
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Mol Ther Nucleic Acids
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NYU Cardiovascular Research Center, NYU Grossman School of Medicine, New York, NY 100016, USA.
Altered protein conformation can cause incurable neurodegenerative disorders. Mutations in , the gene encoding neuroserpin, can alter protein conformation resulting in cytotoxic aggregation leading to neuronal death. Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a rare autosomal dominant progressive myoclonic epilepsy that progresses to dementia and premature death.
View Article and Find Full Text PDFInt J Cardiovasc Imaging
January 2025
Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, USA.
Parametric mapping has become a standard of care technique for the non-invasive assessment of myocardial edema and fibrosis. Conventional MOLLI-based T1 mapping is susceptible to many confounding effects particularly in the pediatric population. The requirement for compliant breath holds is a major limitation for younger or more ill patients.
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