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A computational workflow for modeling complex patient-specific coronary stenting cases.
Comput Methods Programs Biomed
February 2025
Laboratory of Biological Structures Mechanics (LaBS) - Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy. Electronic address:
Article Synopsis
- * The researchers improved their modeling techniques by incorporating varying mechanical properties in the artery walls and recognizing different plaque types, leading to more realistic simulations reflecting real-life conditions.
- * Results showed that the new simulation framework accurately predicted clinical outcomes, with less than 15% error in lumen area recovery, making it a valuable tool for understanding stent performance in overstretched arteries.
One single drug-coated balloon for all shapes/diameters? Neointimal proliferation inhibition in porcine peripheral arteries.
PLoS One
January 2023
Clinical and Experimental Interventional Cardiology, University of Saarland, Homburg, Saar, Germany.
Background: Long diseased vessel segments of peripheral arteries may display irregular shapes with different diameters. The aim of this study was to investigate inhibition of neointimal proliferation in porcine peripheral vessels with different diameters covered by one single hyper-compliant drug-coated balloon (HCDCB), compared to conventional drug-coated balloons (DCB), each selected according to the respective vessel diameter.
Methods And Results: Neointimal proliferation was stimulated in proximal and distal segments of the peripheral arteries by balloon overstretch and stent implantation.
Introduction of a New ex vivo Porcine Coronary Artery Model: Evaluation of the Direct Vascular Injury after Stent Implantation with and without Dogbone Effect.
Eur Surg Res
January 2023
Medical Device Lab, Ostbayerische Technische Hochschule (OTH), Regensburg, Germany.
Introduction: Neointimal hyperplasia after percutaneous coronary intervention remains a major determinant of in-stent restenosis (ISR). The extent of mechanical vessel injury correlates with ISR. A new ex vivo porcine stent model was introduced and evaluated comparing different stent designs.
View Article and Find Full Text PDFHybrid surgery techniques for the treatment of in-stent restenosis after 5 years of femoral artery self-expanding bare-metal stent implantation: A case report.
Medicine (Baltimore)
March 2022
Department of General Surgery, Linping Campus, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Rationale: Lower extremity arteriosclerosis obliterans (ASO) disease is caused by the formation of atherosclerotic plaque in the femoral artery, which causes the stenosis and occlusion of lower legs, and then leads to chronic limb ischemia. Stent intervention is the most common treatment for ASO in the lower extremities, although there is a risk of overstretching or fracturing the stent, resulting in stent rupture. We provide a unique method for treating stent rupture.
View Article and Find Full Text PDFEffect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film-Coated Coronary Stent Loaded With Mycophenolic Acid.
Front Bioeng Biotechnol
October 2021
Korea Cardiovascular Stent Research Institute, Jangsung, South Korea.
Titanium is commonly used in blood-exposed medical devices because it has superior blood compatibility. Mycophenolic acid inhibits the proliferation of vascular smooth muscle cells. This study examined the effect of a non-polymer TiO thin film-coated stent with mycophenolic acid in a porcine coronary overstretch restenosis model.
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