Two appetitive conditioning experiments with rats investigated whether the degree of generalization between a compound and its component parts is fixed or variable. Both experiments used a two-stage transfer design. In Stage 1, the elemental groups learned that a compound and its component parts signaled the same outcome (i.e. C+, D+, CD+), whereas the configural groups learned that a compound and its component parts signaled different outcomes (i.e. C+, D+, CD-, where '+' is pellets and '-' is no pellets). In Stage 2, the rats were tested for reductions in generalization. Experiment 1 found no evidence that past configural learning reduced generalization when a new set of alike-treated A and B elements were presented in compound for the first time. Experiment 2 found no evidence that past configural learning reduced generalization when the stimuli of Stage 1 were presented in a new C-, D-, CD+ relation. In contrast to findings with humans, these results suggest that past experience plays a minor role in how stimuli are encoded in animal conditioning.
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http://dx.doi.org/10.1016/s0376-6357(02)00011-6 | DOI Listing |
Top Curr Chem (Cham)
January 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.
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View Article and Find Full Text PDFPlant Foods Hum Nutr
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Facultad de Industrias Alimentarias, Universidad Nacional Agraria La Molina, Lima, Peru.
This review aimed to explore the impact of extrusion on Andean grains, such as quinoa, kañiwa, and kiwicha, highlighting their macromolecular transformations, technological innovations, and contributions to food security. These grains, which are rich in starch, high-quality proteins, and antioxidant compounds, are versatile raw materials for extrusion, a continuous and efficient process that combines high temperatures and pressures to transform structural and chemical components. Extrusion improves the digestibility of proteins and starches, encourages the formation of amylose-lipid complexes, and increases the solubility of dietary fiber.
View Article and Find Full Text PDFLangmuir
January 2025
Hubei Key Laboratory of Oil and Gas Exploration and Development Theory and Technology (China University of Geosciences), Wuhan 430074, China.
The strong solid-liquid interaction leads to the complicated occurrence characteristics of shale oil. However, the solid-liquid interface interaction and its controls of the occurrence state of shale oil are poorly understood on the molecular scale. In this work, the adsorption behavior and occurrence state of shale oil in pores of organic/inorganic matter under reservoir conditions were investigated by using grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:
Pomegranate peel polyphenols (PPP) are natural compounds known for their various biological activities; however, they are easily degraded by environmental conditions, leading to a reduction in their biological activity and health benefits. Therefore, improving the stability of PPP is a critical question that needs to be addressed. This study aimed to evaluate the efficacy of five common microcapsule wall materials-carboxymethyl cellulose sodium (CMCNa), sodium alginate (SA), gum Arabic (GA), beta-cyclodextrin (β-CD), and hydroxypropyl starch (HPS)-in encapsulating PPP to enhance its stability and antioxidant activity.
View Article and Find Full Text PDFComput Biol Chem
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Drug Discovery and Development Laboratory (DDD Lab), Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:
Multiple myeloma (MM) is the second most frequently diagnosed hematological malignancy, presenting limited treatment options with no curative potential and significant drug resistance. Recent studies involving genetic knockdown established the crucial role of GRK6 in upholding the viability of MM cells, emphasizing the need to identify potential inhibitors. Computational exploration of GRK6 inhibitors has not been attempted previously.
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