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Parkin characteristics and blood biomarkers of Parkinson's disease in WPBLC study.
Front Aging Neurosci
February 2025
Department of Neurology, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou, China.
Background: The exact mechanisms of PD are unclear, but Parkin-mediated mitophagy dysfunction is believed to play a key role. We investigated whether blood levels of Parkin and other biomarkers are linked to the risk of developing PD.
Methods: Baseline blood measures of Parkin and other biomarkers, including Homocysteine, carcinoembryonic antigen, Urea, total proteins, total cholesterol, creatine kinase, and albumin, were collected from 197 clinically diagnosed Parkinson's disease participants and 107 age-matched healthy controls in Wenzhou Parkinson's Biomarkers and Living Characteristics study.
Biliary-intestinal anastomosis leads to alterations in intestinal flora and its flora metabolites and increases the risk of long-term postoperative complications: a case-control study.
Front Microbiol
February 2025
Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, China.
Objective: Pancreaticoduodenectomy (PD) is a major surgical intervention that encompasses the resection of multiple organs and the reconstruction of the digestive tract, with reconstructive procedures including pancreatico-enteric, bilioenteric, and gastroenteric anastomoses. Prior research has documented a high incidence of long-term complications following PD, which significantly impact patient prognosis and survival, however, the underlying mechanisms remain elusive. Evidence from previous studies suggests that biliary-intestinal anastomosis modifies biliary tract anatomy, altering bile flow into the gut and potentially affecting the gut microbiota and its metabolites.
View Article and Find Full Text PDFβ-Ionone Treatment Enhances the Antioxidant Capacity in Postharvest Broccoli ( L. var. ) by Maintaining the Levels of Bioactive Substances.
Foods
February 2025
Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Hwamei College of Life and Health Sciences, Zhejiang Wanli University, Ningbo 315100, China.
Broccoli is prone to nutrient loss during postharvest storage due to its high respiratory metabolism. In this study, we investigated the effects of 0.1 mm β-ionone on bioactive substances and antioxidant capacity during postharvest storage of broccoli.
View Article and Find Full Text PDFRecent Advances on the Role of B Vitamins in Cancer Prevention and Progression.
Int J Mol Sci
February 2025
Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA.
Water-soluble B vitamins, mainly obtained through dietary intake of fruits, vegetables, grains, and dairy products, act as co-factors in various biochemical processes, including DNA synthesis, repair, methylation, and energy metabolism. These vitamins include B1 (Thiamine), B2 (Riboflavin), B3 (Niacin), B5 (Pantothenic Acid), B6 (Pyridoxine), B7 (Biotin), B9 (Folate), and B12 (Cobalamin). Recent studies have shown that besides their fundamental physiological roles, B vitamins influence oncogenic metabolic pathways, including glycolysis (Warburg effect), mitochondrial function, and nucleotide biosynthesis.
View Article and Find Full Text PDFMetabolomic analysis suggests thiamine monophosphate as a potential marker for mesenchymal stem cell transplantation outcomes in patients with SLE.
Lupus Sci Med
March 2025
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Objective: The objective of this research is to identify metabolic markers associated with successful treatment by evaluating the effect of mesenchymal stem cell transplantation (MSCT) on the metabolic profiles of patients with SLE.
Methods: Plasma samples were collected from 20 patients with SLE before and after MSCT. Principal component analysis (PCA) was used to distinguish pretreatment and post-treatment groups and pathway analysis for identifying involved metabolic pathways.
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