It is well known that, in rabbits, the allotypes of the b locus carried by the light chains of the IgG molecules cross-react. Nothing similar has been described for the allotypes of the a locus carried by the heavy chains of the IgG molecules. This paper describes a cross-reaction between the rabbit allotypic markers Aa1 and Aa2 of the a locus. This phenomenon became evident in successive I(125)-labelled IgG precipitation experiments with a particular serum.
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