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Proton Transfer via Arginine with Suppressed p Mediates Catalysis by Gentisate and Salicylate Dioxygenase.
J Phys Chem B
July 2024
Department of Chemistry, College of Staten Island, City University of New York, Staten Island, New York 10314, United States.
Gentisate and salicylate 1,2-dioxygenases (GDO and SDO) facilitate aerobic degradation of aromatic rings by inserting both atoms of dioxygen into their substrates, thereby participating in global carbon cycling. The role of acid-base catalysts in the reaction cycles of these enzymes is debatable. We present evidence of the participation of a proton shuffler during catalysis by GDO and SDO.
View Article and Find Full Text PDFHell's Gate Globin-I from Displays a Unique Temperature-Independent pH Sensing Mechanism Utililized a Lipid-Induced Conformational Change.
Int J Mol Sci
June 2024
School of Biological Sciences, University of Essex, Wivenhoe Park Colchester, Essex CO4 3SQ, UK.
Hell's Gate globin-I (HGb-I) is a thermally stable globin from the aerobic methanotroph . Here we report that HGb-I interacts with lipids stoichiometrically to induce structural changes in the heme pocket, changing the heme iron distal ligation coordination from hexacoordinate to pentacoordinate. Such changes in heme geometry have only been previously reported for cytochrome c and cytoglobin, linked to apoptosis regulation and enhanced lipid peroxidation activity, respectively.
View Article and Find Full Text PDFLipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles.
Proc Natl Acad Sci U S A
January 2024
Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent behavior necessary for an efficient delivery of the cargo-the so-called endosomal escape. However, it is still an empirical exercise to identify optimally performing lipids. Here, we study two well-known ionizable lipids, DLin-MC3-DMA and DLin-DMA using a combination of experiments, multiscale computer simulations, and electrostatic theory.
View Article and Find Full Text PDFRates of iron(III) reduction coupled to elemental sulfur or tetrathionate oxidation by acidophilic microorganisms and detection of sulfur intermediates.
Res Microbiol
January 2024
Federal Institute for Geosciences and Natural Resources (BGR), Stilleweg2, 30655 Hannover, Germany. Electronic address:
Bioleaching processes and acid mine drainage (AMD) generation are mainly driven by aerobic microbial iron(II) and inorganic sulfur/compound oxidation. Dissimilatory iron(III) reduction coupled to sulfur/compound oxidation (DIRSO) by acidophilic microorganisms has been described for anaerobic cultures, but iron reduction was observed under aerobic conditions as well. Aim of this study was to explore reaction rates and mechanisms of this process.
View Article and Find Full Text PDFBreaking the Photostability and pH Limitation of Halo-Fluoresceins through Chitosan Conjugation.
Adv Mater
April 2023
Analytical and Testing Centre, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu, 610064, China.
Halo-fluoresceins are widely used in cell and tissue staining, intracellular sensing, and photodynamic therapy, but their notorious photo-instability and pH dependence restrict their applications, especially in long-term visible light exposure and acidic environments. To overcome these limitations, here a strategy is proposed of conjugating chitosan with the carboxyl group of halo-fluorescein (CS-halofluorescein). The cross-linked polymer chains and the hydrogen-bonding networks of chitosan help shielding out O from direct attacking the encapsulated halo-fluoresceins, leading to a two orders of magnitude lower photobleaching rate.
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