In 26 children presenting with chronic erosive gastritis, an unspecific proteinase-inhibitor potential was identified in the basal portion of the gastric juice in the period of exacerbation and incomplete remission. Revealed in the gastric content in the period of exacerbation was augmentation of the activity of elastase- and tripsinlike proteinases. In the period of remission, the indices have been shown to be lower but insignificantly, remaining significantly higher compared to those indices in the control group. There was a decrease in the antiproteinase potential in the period of exacerbation getting even more lowered during the period of incomplete remission. The findings secured suggest to us a manifest imbalance in the local proteinase-inhibitor system. A conclusion has been reached that exhaustion of the local inhibitor potential and ensuing high activity of unspecific proteinases result in destructive changes in the gastric mucosa, thus, having pathogenetic significance in the development of chronic inflammatory-and-destructive diseases.
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