AI Article Synopsis
- The text reviews the concept of nucleolar-organizing regions (NORs) in human somatic cell interphase nuclei, detailing their structure and function.
- It discusses various methods for revealing these regions and provides classifications for their characteristics.
- Finally, the review highlights the differences in NORs under normal conditions versus those affected by diseases of the blood system, particularly hemoblastosis.
Article Abstract
Data on concept of the nucleolar-organizing regions of the human somatic cell interphase nuclei, methods of their revealing, classifications, as well as their structural-functional peculiarities in norm and under different diseases of blood system, in particular under hemoblastosis, are reviewed in historical aspect.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Utility of ultrasound in thoracic anesthesia.
Best Pract Res Clin Anaesthesiol
March 2024
Department of Anaesthesiology, Intensive care and Emergency Medicine, OLV Clinic, Aalst, Belgium. Electronic address:
The use of ultrasound (US) in the perioperative clinical management should be goal-directed, rapid, and reproducible. Thoracic US enables detailed examinations of vital structures, such as the airway, lung, pleural space, diaphragm, and heart. This chapter focuses on the value of US as a bedside tool to assess anatomy, guide procedures, and monitor vital organ function in patients undergoing thoracic surgery.
View Article and Find Full Text PDFDefining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable Biopharmaceuticals.
Adv Sci (Weinh)
January 2025
Department of Materials Science & Engineering, Stanford University, Stanford, CA, 94305, USA.
Biopharmaceuticals are the fastest-growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamers are used to prevent protein aggregation, which significantly extends shelf-life. Unfortunately, these excipients are themselves unstable, oxidizing rapidly into 100s of distinct compounds, some of which cause severe adverse events in patients.
View Article and Find Full Text PDFDeciphering the Radial Ligand Effect of Biomimetic Amino Acid toward Stable Alkaline Oxygen Evolution.
Inorg Chem
January 2025
School of Materials Science and Engineering, China University of Petroleum, Qingdao 266580, PR China.
Mismatched electron and proton transport rates impede the manifestation of effective performance of the electrocatalytic oxygen evolution reaction (OER), thereby limiting its industrial applications. Inspired by the natural protein cluster in PS-II, different organic-inorganic hybrid electrocatalysts were synthesized via a hydrothermal method. -Toluidine (PT), benzoic acid (BA), and -aminobenzoic acid (PABA) were successfully intercalated into NiFe-LDH.
View Article and Find Full Text PDFDecoding Salience: A Functional Magnetic Resonance Imaging Investigation of Reward and Contextual Unexpectedness in Memory Encoding and Retrieval.
Hum Brain Mapp
January 2025
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.
The present study investigated the neuromodulatory substrates of salience processing and its impact on memory encoding and behaviour, with a specific focus on two distinct types of salience: reward and contextual unexpectedness. 46 Participants performed a novel task paradigm modulating these two aspects independently and allowing for investigating their distinct and interactive effects on memory encoding while undergoing high-resolution fMRI. By using advanced image processing techniques tailored to examine midbrain and brainstem nuclei with high precision, our study additionally aimed to elucidate differential activation patterns in subcortical nuclei in response to reward-associated and contextually unexpected stimuli, including distinct pathways involving in particular dopaminergic modulation.
View Article and Find Full Text PDFNGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer.
Pharm Dev Technol
January 2025
Department of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (H-NMR). Pharmacokinetic results showed that the accumulation of QUE in plasma of the NPC-QUE-L group was 1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!