Study Objective: To investigate whether total IV anesthesia with ketamine, propofol, and fentanyl affects the frequency of postoperative psychosis emergence or confusion in schizophrenic patients.

Design: Prospective, controlled study.

Setting: Hirosaki National Hospital and Hakodate Watanabe Hospital.

Patients: 76 ASA physical status I and II schizophrenic patients taking chronic antipsychotic drugs and schedule for orthopedic surgery of extremities.

Interventions: In Group A (n = 38) patients, anesthesia was maintained with sevoflurane, nitrous oxide, and fentanyl. In Group B (n = 38) patients, anesthesia was maintained with ketamine, propofol, and fentanyl.

Measurements And Main Results: The frequency of psychosis emergence or confusion (54%) in Group A during the first 48 hours after surgery was significantly higher than the 30% figure in Group B.

Conclusion: Ketamine, when combined with propofol and fentanyl, is an appropriate anesthetic drug for schizophrenic patients.

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Source
http://dx.doi.org/10.1016/s0952-8180(01)00363-4DOI Listing

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