We have utilized differential display polymerase chain reaction to investigate the gene expression of hematopoietic progenitor cells from adult bone marrow and umbilical cord blood. A differentially expressed gene was identified in CD34+ hematopoietic progenitor cells, with low expression in CD34- cells. We have obtained the full coding sequence of this gene which we designated human mammalian ependymin-related protein 1 (MERP1). Expression of MERP1 was found in a variety of normal human tissues, and is 4- and 10-fold higher in adult bone marrow and umbilical cord blood CD34+ cells, respectively, compared to CD34- cells. Additionally, MERP1 expression in a hematopoietic stem cell enriched population was down-regulated with proliferation and differentiation. Conceptual translation of the MERP1 open reading frame reveals significant homology to two families of glycoprotein calcium-dependant cell adhesion molecules: ependymins and protocadherins.
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EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β.
EMBO J
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School of Medicine, South China University of Technology, Guangzhou, China.
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View Article and Find Full Text PDFThe human batokine EPDR1 regulates β-cell metabolism and function.
Mol Metab
December 2022
The Novo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200 Denmark; Department of Forest genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden. Electronic address:
Article Synopsis
- EPDR1 is a human batokine that plays a role in regulating mitochondrial respiration and thermogenesis in brown fat, but its effects on pancreatic β-cells and glucose metabolism remain unexplored.
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EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex.
J Biol Chem
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Department of Chemistry & Biochemistry, University of Arizona, Tucson, Arizona, USA; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA; Comprehensive Cancer Center, University of Arizona, Tucson, Arizona, USA. Electronic address:
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View Article and Find Full Text PDFLong non-coding RNA SDCBP2-AS1 delays the progression of ovarian cancer via microRNA-100-5p-targeted EPDR1.
World J Surg Oncol
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Wuhan Wuchang Hospital, Wuhan University of Science and Technology, 505 Luoshi Road, South District, Wuchang Hospital, Hongshan District, Wuhan, 430061, Hubei, China.
Background: Dysregulation of long non-coding RNAs has been implied to connect with cancer progression. This research was to decipher the mechanism of long non-coding RNA SDCBP2-AS1 in ovarian cancer (OC) through regulation of microRNA (miR)-100-5p and ependymin-related protein 1 (EPDR1).
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EPDR1 is related to stages and metastasize in bladder cancer and can be used as a prognostic biomarker.
BMC Urol
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Medical College of Soochow University, Suzhou, Jiangsu, China.
Background: Bladder cancer (BLCA) is a malignant urothelial carcinoma and has a high mortality rate. EPDR1 (ependymin related 1) is a type II transmembrane protein and related to calcium-dependent cell adhesion.
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