A 40-year-old depressed patient with alpha(1)-antitrypsin deficiency and severe emphysema developed bronchospasm shortly after an initial electroconvulsive therapy (ECT), resulting in discontinuation of treatment. The use of ECT in patients with emphysema and prevention of respiratory complications are discussed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Mildly Elevated Liver Transaminase Levels: Causes and Evaluation.
Am Fam Physician
December 2024
St. Luke's Family Medicine Residency-Sacred Heart Campus, Allentown, Penn.
Approximately 10% to 20% of the general population has elevated liver chemistry levels, including aspartate and alanine transaminases. Elevated transaminase levels may be associated with significant underlying liver disease and increased risk of liver-related and all-cause mortality. The most common causes of mildly elevated transaminase levels (two to five times the upper limit of normal) are metabolic dysfunction-associated steatotic liver disease (MASLD) and alcoholic liver disease.
View Article and Find Full Text PDFQuantitative BAL: a suitable method for the assessment of epithelial lining fluid in alpha-1 antitrypsin deficiency?
Thorax
December 2024
Respiratory Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
Background: Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that treatment administration increases alpha-1 antitrypsin (AAT) levels and/or anti-neutrophil elastase inhibitory capacity (ANEC) in the lung. Early-phase studies often encounter high interindividual variability of BAL results, primarily stemming from the inherent dilution characteristics of returned BAL fluid.
View Article and Find Full Text PDFDoes hypersialylation compensate the functional Alpha1-AntiTrypsin (A1AT) deficiency in all critically ill patients?
Biochimie
November 2024
Laboratoire de Biochimie « Hormonologie, Métabolisme, Nutrition & Oncologie », CHU, F-59037 Lille, France; Univ. Lille ULR 4483 - IMPECS, Institut Pasteur Lille, F-59000 Lille, France.
Alpha-1 antitrypsin (A1AT) is the major circulating serine protease inhibitor. Hypersialylated glycoforms (HSG) are produced to boost A1AT anti-inflammatory and anti-protease properties. Their occurrence and prognostic impact outside severe COVID-19 or community-acquired pneumonia are unknown.
View Article and Find Full Text PDFAlpha-1 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: A nationwide cohort study.
J Intern Med
December 2024
Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark.
Article Synopsis
- α-Antitrypsin deficiency leads to higher elastase activity and elastin breakdown, potentially contributing to cancer risks.
- A study involving over 29,000 individuals in Denmark shows that those with this deficiency have significantly higher rates of skin cancer, leukemia, and liver cancer compared to those without the deficiency.
- The risk for skin cancer was particularly elevated in individuals with other health issues like chronic obstructive pulmonary disease (COPD) and skin diseases, indicating a compounded risk for certain populations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!