A fatal case of gastric mucormycosis and diabetic ketoacidosis.

Endocr Pract

Department of Internal Medicine, Medical School, and Diabetes and Nutrition Division of Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil.

Published: August 2002

AI Article Synopsis

  • A 17-year-old woman with diabetes developed gastric mucormycosis after experiencing ketoacidosis, leading to severe gastrointestinal bleeding.
  • Medical evaluations revealed an invasive fungal infection through endoscopy, but initial treatments were unsuccessful, resulting in the patient's death.
  • This case highlights that while mucormycosis typically affects the face and eyes, it can also occur in the gastrointestinal tract, demonstrating its potential severity.

Article Abstract

Objective: To describe a case of gastric mucormycosis in conjunction with severe bleeding in a young woman, which occurred after an episode of ketoacidosis and had a fatal outcome.

Methods: We present a case report, including detailed clinical and pathologic findings in a woman with gastric mucormycosis associated with severe bleeding.

Results: A 17-year-old woman sought medical assistance for diabetic ketoacidosis and severe epigastric pain. Chest radiography showed normal findings, and blood and urine cultures were negative for bacterial growth. Endoscopy disclosed an extensive ulcerated lesion involving the greater curvature and posterior wall of the stomach. Biopsy specimens demonstrated the presence of invasive mucormycosis. Treatment with amphotericin B was initiated, but severe persistent gastrointestinal bleeding resulted in the patient's demise.

Conclusion: In conjunction with diabetic ketoacidosis, severe infection by Mucor has been reported mainly in the rhino-orbital area. Although uncommon, the gastrointestinal tract can also be involved. In the case described, severe hemorrhage ensued and caused the patient's death.

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Source
http://dx.doi.org/10.4158/EP.8.1.44DOI Listing

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