AI Article Synopsis
- Primary cutaneous diffuse large B-cell lymphoma (DLBCL) is a rare type of lymphoma observed primarily in elderly patients, with a higher incidence in men.
- Cases were analyzed using specific antibodies and genetic tests to understand the characteristics better.
- Among patients with lesions on the lower extremities, recurrence rates were 50%, compared to 18% for lesions in other areas, highlighting a potential difference in outcomes based on tumor location.
Article Abstract
Primary cutaneous diffuse large B-cell lymphoma (DLBCL) is an uncommon lymphoma. Some authors have suggested that large B-cell lymphoma can be segregated based on anatomic site, with tumors of the lower extremity being unique. We report 15 cases of primary cutaneous DLBCL. Each case was analyzed immunohistochemically using antibodies specific for CD3, CD5, CD10, CD20, bcl-2, bcl-6, and p53. Polymerase chain reaction analysis for t(14;18)(q32;q21) also was performed. There were 13 men and 2 women (median age, 64 years). Thirteen tumors were composed predominantly of centroblasts, and 2 were immunoblastic. There was a median follow-up of 72 months. Of the 4 patients with primary cutaneous DLBCL of the lower extremity (thigh, knee, leg), 2 (50%) experienced a recurrence and 1 patient died of disease. In the non-lower extremity cases, 18% (2/11) recurred and no patients died of disease. We conclude that primary cutaneous DLBCL usually occurs in elderly patients with a male predominance. Recurrences are common, but death of disease is rare.
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| http://dx.doi.org/10.1309/edal-r8ha-u3el-t37d | DOI Listing |
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