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Biochemical markers in hand osteoarthritis: a path to precision medicine.
Rheumatol Int
January 2025
Clinic of Rheumatology, University Hospital St. Marina, Varna, 9010, Bulgaria.
Hand osteoarthritis (HOA) is a heterogeneous joint disease with high radiographic and symptomatic prevalence. The diagnosis of HOA is based on clinical and radiographic features. The identification of potential biomarkers for diagnosis, prognosis, disease severity assessment, and therapeutic efficacy evaluation of НОА remains an active area of research.
View Article and Find Full Text PDFPsychological intervention for knee osteoarthritis: a systematic review and meta-analysis.
Psychol Health Med
January 2025
Department of Physical Therapy, School of Health Sciences, Shinshu University, Matsumoto, Japan.
This systematic review and meta-analysis aimed to evaluate the effectiveness of psychological interventions compared to standard rehabilitation in patients with knee osteoarthritis (OA). Given the recognized influence of psychological factors in OA management, the review assessed their impact on pain, functional disability, and self-efficacy. A comprehensive search was performed across multiple databases, including PubMed, PsycINFO, CINAHL, the Cochrane Central Register of Controlled Trials, Web of Science, OpenGrey, and ClinicalTrials.
View Article and Find Full Text PDFComparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis.
Biomedicines
January 2025
Department of Trauma and Orthopaedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital Erlangen, 91054 Erlangen, Germany.
The present Bayesian network meta-analysis compared the efficacy of intra-articular injections of different molecular weights of hyaluronic acid (HA) in patients with knee osteoarthritis. In November 2024, the following databases were accessed: PubMed, Web of Science, Google Scholar, and Embase. All randomised controlled trials investigating the efficacy of intra-articular HA injections for knee osteoarthritis were accessed.
View Article and Find Full Text PDFThis meta-analysis focuses on the controversial efficacy and safety of microfragmented adipose tissue (MFAT) as compared with platelet-rich plasma (PRP) in the clinical treatment of knee osteoarthritis (KOA). We have attempted to provide an evidence-based medicine protocol for the conservative treatment of KOA. Researchers collected and compared randomized controlled trials (RCTs) that used microfragmented adipose tissue and platelet-rich plasma to treat knee osteoarthritis.
View Article and Find Full Text PDFCurrent status of nanofat in the management of knee osteoarthritis: A systematic review.
World J Orthop
January 2025
Department of Regenerative Medicine, Mother Cell Regenerative Centre, Tiruchirappalli 620017, Tamil Nadu, India.
Background: Osteoarthritis (OA) is a prevalent joint disorder requiring innovative treatment approaches.
Aim: To evaluate the use of nanofat, a specialized form of adipose tissue-derived cells, in the treatment of OA, by examining its efficacy, safety profile, mechanisms of action, comparative effectiveness, and long-term outcomes.
Methods: A comprehensive review of preclinical studies, clinical trials, and investigations was conducted.
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