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Reverse Time-to-Death as Time-Scale in Time-to-Event Analysis for Studies of Advanced Illness and Palliative Care.
Stat Med
February 2025
Programme in Health Services & Systems Research, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
Incidence of adverse outcome events rises as patients with advanced illness approach end-of-life. Exposures that tend to occur near end-of-life, for example, use of wheelchair, oxygen therapy and palliative care, may therefore be found associated with the incidence of the adverse outcomes. We propose a concept of reverse time-to-death (rTTD) and its use for the time-scale in time-to-event analysis based on partial likelihood to mitigate the time-varying confounding.
View Article and Find Full Text PDFCancer Stem Cell Regulation as a Target of Therapeutic Intervention: Insights into Breast, Cervical and Lung Cancer.
Cell Biochem Biophys
January 2025
Division of Biomedical and Life Sciences, School of Science, Navrachana University, Vadodara, Gujarat, India.
Cancer Stem Cells (CSCs) play an important role in the development, resistance, and recurrence of many malignancies. These subpopulations of tumor cells have the potential to self-renew, differentiate, and resist conventional therapy, highlighting their importance in cancer etiology. This review explores the regulatory mechanisms of CSCs in breast, cervical, and lung cancers, highlighting their plasticity, self-renewal, and differentiation capabilities.
View Article and Find Full Text PDFAn interactive simulator to deepen the understanding of Guyton's venous return curve.
J Physiol Sci
January 2025
Department of Hematology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, 252-0374, Sagamihara, Kanagawa, Japan.
Mean circulatory filling pressure, venous return curve, and Guyton's graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or understand them adequately. To deepen students' understanding of the graphical analysis, in place of having to perform live animal experiments, we developed an interactive cardiovascular simulator, as a self-learning tool, as a web application.
View Article and Find Full Text PDFPiloting creative engagement strategies to explore themes of parenthood with fathers.
Front Child Adolesc Psychiatry
January 2024
Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Introduction: The role of the arts in health is increasingly recognised, with participatory arts-based approaches facilitating public engagement. However, little is known about men's involvement in art-based participatory research. We aimed to investigate how men who are fathers may be engaged creatively to explore experiential aspects of fathering and parenthood.
View Article and Find Full Text PDFNetwork analysis of caffeine use disorder, withdrawal symptoms, and psychiatric symptoms.
BMC Psychiatry
January 2025
Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Objective: Caffeine Use Disorder (CUD) is not currently recognized as a formal diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). However, recent studies within the DSM-5 context have explored this issue. Also, this disorder is closely associated with caffeine withdrawal symptoms, which are formally recognized as a diagnosis in the DSM-5.
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