Background: Complete sternotomy is the standard approach in cardiac surgery, and coronary artery bypass grafting (CABG) is the most common revascularization procedure to use this approach. A new technique has been developed that permits complete surgical revascularization with arterial grafts in awake patients. This technique, which we refer to as awake coronary artery bypass grafting, avoids general anesthesia, mechanical ventilation, and extracorporeal circulation, thereby creating the least invasive method for heart operations yet described.

Methods: A thoracic epidural catheter was placed at T2-T3 level one day before surgery. In 12 patients, single (n = 6), double (n = 5), or triple (n = 1) vessel coronary artery bypass grafting was performed without general anesthesia. In six patients, this procedure was performed after complete median sternotomy.

Results: Ten patients remained awake throughout the whole procedure. Two patients required secondary intubation due to incomplete analgesia in one case and pneumothorax in the other. Procedural time was 98.2 +/- 19.8 minutes. Intermediate care stay was 4.9 +/- 0.6 hours. There were no perioperative complications, and early angiographic results before discharge were excellent in all patients.

Conclusions: The data presented show the feasibility and safety of complete surgical revascularization via median sternotomy using arterial grafts without general anesthesia. This approach shortens recovery time and increases patient comfort, suggesting that outpatient cardiac surgery may eventually be possible.

Download full-text PDF

Source

Publication Analysis

Top Keywords

coronary artery
16
artery bypass
16
bypass grafting
16
general anesthesia
12
complete sternotomy
8
cardiac surgery
8
complete surgical
8
surgical revascularization
8
arterial grafts
8
patients
6

Similar Publications

Impact of remnant cholesterol on short-term and long-term prognosis in patients with prediabetes or diabetes undergoing coronary artery bypass grafting: a large-scale cohort study.

Cardiovasc Diabetol

January 2025

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Rd, Xicheng District, Beijing, 100037, People's Republic of China.

Background: Remnant cholesterol (remnant-C) contributes to atherosclerotic cardiovascular disease (ASCVD), particularly in individuals with impaired glucose metabolism. Patients with impaired glucose metabolism and ASCVD remain at significant residual risk after coronary artery bypass grafting (CABG). However, the role of remnant-C in this population has not yet been investigated.

View Article and Find Full Text PDF

Madecassoside mitigates acute myocardial infarction injury by activating the PKCB/SPARC signaling pathway.

Acta Pharmacol Sin

January 2025

Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.

The current treatments and drugs of myocardial infarction (MI) remain insufficient. In recent years, natural products have garnered significant attention for their potential in treating cardiovascular diseases due to their availability and lower toxicity. Saponins, in particular, showed promising effects for cardiac protection.

View Article and Find Full Text PDF

Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that it may present. To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases.

View Article and Find Full Text PDF

Heart disease is a category of various conditions that affect the heart, which includes multiple diseases that influence its structure and operation. Such conditions may consist of coronary artery disease, which is characterized by the narrowing or clotting of the arteries that supply blood to the heart muscle, with the resulting threat of heart attacks. Heart rhythm disorders (arrhythmias), heart valve problems, congenital heart defects present at birth, and heart muscle disorders (cardiomyopathies) are other types of heart disease.

View Article and Find Full Text PDF

Cardiac-Urogenital Syndrome (CUGS) is a recently identified genetic disease characterized by urogenital, diaphragmatic, ophthalmic, and cardiac abnormalities caused by heterozygous pathogenic variants in the Myelin Regulatory Factor (MYRF) gene. The complete spectrum of disease characteristics and prevalence is not yet defined. This report documents the first known cases of anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) in MYRF-associated Cardiac-Urogenital Syndrome (MYRF-CUGS).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!