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From errors to excellence: the pre-analytical journey to improved quality in diagnostics. A scoping review.
Clin Chem Lab Med
January 2025
School of Dentistry and Medical Science, Faculty of Science and Health, 110481 Charles Sturt University, Wagga Wagga, NSW, Australia.
This scoping review focuses on the evolution of pre-analytical errors (PAEs) in medical laboratories, a critical area with significant implications for patient care, healthcare costs, hospital length of stay, and operational efficiency. The Covidence Review tool was used to formulate the keywords, and then a comprehensive literature search was performed using several databases, importing the search results directly into Covidence (n=379). Title, abstract screening, duplicate removal, and full-text screening were done.
View Article and Find Full Text PDFEvaluation of pre-analytical factors impacting urine test strip and chemistry results.
Clin Chem Lab Med
January 2025
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Objectives: Careful consideration of the pre-analytical process for urine examination is essential to avoid errors and support accurate results and decision-making. Our objective was to assess the impact of various pre-analytical factors on urine test strip and quantitative chemistry results, including stability, tube type, fill volume, and centrifugation.
Methods: Residual random urine specimens were identified.
Potential of role play as an educational tool in biochemistry to facilitate medical education.
Biochem Mol Biol Educ
January 2025
All India Institute of Medical Sciences, Bathinda, Bathinda, Punjab, India.
Commonly used traditional didactic lecture in biochemistry being non-interactive has several disadvantages which students find boring and difficult to retain. This study reviews the potential of role play to teach biochemistry effectively. Studies published till June 2024 on the topic role play in medical education and biochemistry were searched using 'Ovid Discovery' software showing studies available in PubMed, Embase, and Cochrane databases.
View Article and Find Full Text PDFBenchtop centrifugation: An effective method for reducing lipaemia associated interference in grossly lipaemic samples?
Ann Clin Biochem
January 2025
Department of Clinical Chemistry, University Hospitals Sussex NHS Trust, Chichester, UK.
Background: Grossly lipaemic samples are a significant cause of analytical errors, potentially impacting patient care. The causes of lipaemia are varied and often unavoidable, while methods to reduce lipaemia through gold-standard ultracentrifugation are limited by availability, transportation and cost. Benchtop centrifugation has been proposed as an alternative method to reduce lipaemia.
View Article and Find Full Text PDFInvestigating the incremental value of urine sediment reporting in emergency medicine with a Sysmex UN urinalysis system.
Adv Lab Med
December 2024
Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy.
Objectives: Urinalysis is widely used and is also frequently requested in emergency situations for screening hypovolemia, urinary tract infections, diabetes, ketoacidosis and hematuria. Our aim was to evaluate the impact of reporting urinary sediment in emergency department specimens with the Sysmex UN system.
Methods: We evaluated urinalyses requested by the emergency department over a three-month period and examined red blood cell count interference, compared leukocyte esterase dipsticks to cytofluorimetric leukocyte count and nitrites to cytofluorimetric bacterial count.
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