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The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey.
Prev Med Rep
January 2025
Faculty of Kinesiology and Recreation Management, University of Manitoba (Fort Garry campus), 420 University Crescent, Winnipeg, Manitoba R3T 2N2, Canada.
Objectives: To investigate the prevalence of spine symptoms and spine disability, self-care and care seeking behaviors in a random sample of Indigenous adults residing in Cross Lake, northern Manitoba, Canada.
Study Design And Setting: Orally administered survey in Cree or English to a representative sample of Pimicikamak citizens from the treaty ( = 150/1931 houses) and non-treaty ( = 20/92 houses) land, between May and July 2023. Questions ( = 154) were derived from the 2018 First Nations Regional Health Survey, 2020 Canadian Community Health Survey, and 2021 The Global Burden of Disease study, covering demographics, spine symptoms, chronic conditions, activity limitations, general health, self-care, medication, and satisfaction with care.
Forging the Future: B Cell Activating Factor's Impact on Nephrotic Syndrome.
Malays J Med Sci
December 2024
Nephrology Division, Department of Paediatric, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia.
Nephrotic syndrome is the most common glomerular disease in children. While the exact pathogenesis of nephrotic syndrome is not fully understood, recent research has shed light on some of the underlying mechanisms involved in it. Improvement by B cell depletion therapy using antiCD20 in nephrotic syndrome has led to a paradigm shift from immunoinflammatory disease influenced by T cell dysregulation to B cell involvement in the pathogenesis of nephrotic syndrome.
View Article and Find Full Text PDFFrom Pixels to Prognosis: Artificial Intelligence and Machine Learning Models in Brain Tumour Mutation Prediction.
J Pak Med Assoc
January 2025
Department of Neurosurgery, Aga Khan University Hospital, Karachi, Pakistan.
Brain tumours are a leading cause of death and disability, impacting individuals across all ages, genders, and ethnicities. They are primarily diagnosed using MRI but a precise diagnosis is dependent on the molecular biology of the tumour studied on the pathological specimen. Artificial intelligence and machine learning are forging new paths through diagnostic obstacles, offering the intriguing benefits of non-invasive diagnosis, pattern recognition, and outcome prediction from imaging data.
View Article and Find Full Text PDFThe relationship between the supination resistance test, lower limb biomechanics and the effects of foot orthoses on foot and ankle biomechanics in individuals with posterior tibialis tendon dysfunction during gait.
Gait Posture
January 2025
Deparment of Rehabilitation Sciences, Division of Physical Therapy, Medical University of South Carolina, 151-B Rutledge Avenue, MSC 339, Charleston, SC 29425, United States of America.
Background: Posterior tibialis tendon dysfunction (PTTD) is a debilitating condition that leads to biomechanical changes, for which foot orthoses are often prescribed to attenuate. There is a need to improve the ability to predict these biomechanical alterations, determine the biomechanical effectiveness of foot orthoses, and anticipate their effects on individuals with PTTD during gait.
Research Question: Is the supination resistance test (SRT) reliable, and capable of predicting foot and ankle biomechanics, as well as the biomechanical effects of foot orthoses in individuals with PTTD during gait?
Methods: Twenty-one individuals with PTTD participated with supination resistance measured over two sessions.
Medusa's gaze: Cell traces and fibrils but no collagen in permineralized Jurassic ichthyosaur bone.
iScience
January 2025
Abteilung Paläontologie, Bonner Institut für Organismische Biologie, Universität Bonn, 53115 Bonn, Germany.
Bone is formed by specialized cells whose activity allows bone to grow, change shape, and repair itself. Its composite structure of collagen fibrils and bioapatite nanocrystals gives bone exceptional mechanical strength. Using scanning electron microscopy, we show in fossil ichthyosaurs, 150 to 200 million years old, from the Jurassic of France and the UK, abundant and direct evidence of cellular activity on the fossilized forming, resting, and resorbing surfaces of bone trabeculae, as well as bone fibrils, Sharpey fibers, and cartilage fibers.
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