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Different amounts of isoflavones in various commercially available soy extracts in the light of gene expression-targeted isoflavone therapy.
Phytother Res
January 2010
Department of Molecular Biology, University of Gdańsk, Kładki 24, 80-822 Gdańsk, Poland.
Isoflavones are plant-derived, biologically active compounds that are commonly used as natural drugs or diet supplements in the treatment of menopausal symptoms and as antioxidants. Recently, it was proposed that genistein (4',5,7-trihydroxyisoflavone) may be used in the treatment of patients suffering from Sanfilippo disease (mucopolysaccharidosis type III), a severe genetic disorder for which no therapy is available. A pilot clinical study with this novel therapy, called 'gene expression-targeted isoflavone therapy' (GET IT), indicated that a standardized, genistin-rich soy isoflavone extract is effective in the treatment of such patients.
View Article and Find Full Text PDFComparison of hormonal activity of isoflavone-containing supplements used to treat menopausal complaints.
Menopause
December 2009
Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria.
Objectives: The isoflavones present in red clover and soy are used as an alternative treatment for menopausal complaints and are commercially available as high-dose food supplements. These preparations contain varying amounts of active ingredients, often without detailed specifications. Thus, it is difficult to derive a recommended daily dose, and the reliability of these products is rather low.
View Article and Find Full Text PDFEffects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys.
Metabolism
July 2008
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.
Isoflavones may influence insulin action by means of their well-known receptor-mediated estrogenic activity. However, isoflavones also bind to peroxisome proliferator-activated receptors (PPARs) that are strongly associated with insulin action. Soy protein with its isoflavones has previously been shown to improve glycemic control in diabetic postmenopausal women and to improve insulin sensitivity in ovariectomized monkeys.
View Article and Find Full Text PDFIsoflavone supplements containing predominantly genistein reduce hot flash symptoms: a critical review of published studies.
Menopause
September 2007
Archer Daniels Midland Company, Decatur, IL, USA.
Objective: Several reviews have evaluated the clinical evidence relating isoflavone treatment to the relief of menopausal hot flash symptoms. The majority of these reviews included a variety of isoflavone sources, often without discriminating between the identities of individual isoflavones contained in the study product. An evaluation of published studies using well-characterized isoflavone-containing supplements was conducted to determine whether the observed effects, or lack thereof, were attributable to differences in the composition of isoflavones in study products.
View Article and Find Full Text PDFIncreased serum and testicular androgen levels in F1 rats with lifetime exposure to soy isoflavones.
Reprod Toxicol
July 2004
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada.
The consequences of dietary soy isoflavones on serum and testicular androgen levels were examined in F1 male rats from a multigeneration study investigating the effects of diets varying in isoflavone content. Rats were fed either a soy-free casein based diet (AIN93G) or a diet in which alcohol-washed soy protein replaced casein as the protein source and to which increasing amounts of Novasoy, a commercially available isoflavone supplement were added. Analysis of these diets showed that the isoflavone content in each diet was 0 (diet 1; casein based control), 31.
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