AI Article Synopsis
- The study investigated how Angelica keiskei Koidz. affects liver damage caused by bromobenzene in rats, focusing on lipid peroxidation and enzymatic activity.
- The methanol extract from the plant and its component, cynaroside, significantly reduced elevated lipid peroxide levels caused by bromobenzene.
- Treatment with A. keiskei and cynaroside restored decreased epoxide hydrolase activity, suggesting their potential to protect the liver by enhancing this enzyme that helps detoxify bromobenzene.
Article Abstract
The effects of Angelica keiskei Koidz. on hepatic lipid peroxide and the activities of free radical generating and scavenging enzymes were investigated in bromobenzene-induced hepatic lipid peroxidation in rats. The level of lipid peroxide elevated by bromobenzene was significantly reduced by the methanol extract from the aerial parts of A. keiskei and its component, cynaroside. Epoxide hydrolase activity was decreased significantly by the treatment of bromobenzene. However, the enzyme activity was restored in the liver of rats given the methanol extract and cynaroside. The results suggest that the reduction of bromobenzene-induced hepatic lipid peroxidation by the extract of A. keiskei and cynaroside under our experimental conditions is thought to be through enhancing the activity of epoxide hydrolase, an enzyme removing bromobenzene epoxide.
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| http://dx.doi.org/10.1002/ptr.783 | DOI Listing |
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