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Detailed functional characterization of four nanobodies as positive allosteric modulators of the human calcium-sensing receptor.
Biochem Pharmacol
January 2025
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark. Electronic address:
The calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis, and small-molecule and peptide positive allosteric modulators (PAMs) of CaSR, so-called calcimimetics, are used in the treatment of hyperparathyroidism and hypocalcemic disorders. In this study, four monovalent nanobodies - representing four distinct nanobody families with CaSR PAM activity - were subjected to elaborate pharmacological profiling at the receptor. While Nb5 displayed negligible PAM activity at CaSR in all assays, Nb4, Nb10 and Nb45 all potently potentiated Ca-evoked signalling through a myc epitope-tagged CaSR expressed in HEK293 or HEK293T cells in Gα and Gα protein activation assays and in a Ca/Fluo-4 assay.
View Article and Find Full Text PDFRadiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients.
Cardiovasc Intervent Radiol
June 2024
Radiology and Vascular Imaging, Amplatz Chair in Interventional Radiology, University of Minnesota, Minneapolis, USA.
Purpose: To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA).
Materials And Methods: In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called "Nik jet dissection" which incorporates full hydrodissection and polar artery coagulation.
Severe Acro-osteolysis Mimicking Arthritis Mutilans in a Patient with Primary Hyperparathyroidism: A Case Report.
Curr Rheumatol Rev
July 2024
Department of Propedeutics of Internal Diseases, Medical University of Plovdiv, Medical Faculty, Plovdiv, Bulgaria.
Background: Primary hyperparathyroidism (PHPT) should be considered in the differential diagnosis of a patient with suspected secondary osteoporosis, and severe osteoporosis with multiple fractures is frequently the first clinical manifestation of the disease.
Case Presentation: Mutilating arthritis (arthritis mutilans) can be part of the clinical presentation of a number of rheumatic diseases, most commonly seen in psoriatic arthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, but also in systemic lupus, systemic sclerosis, and multicentric reticulohistiocytosis. Evidence exists that subperiosteal and subchondral bone resorption, seen in PHPT, could induce the so-called 'osteogenic synovitis', which could eventually lead to the development of a secondary osteoarthritis with bone deformities.
Molecular Imaging with F-FDG PET/CT and Tc-MIBI SPECT/CT in Osteitis Fibrosa Cystica Generalisata.
Diagnostics (Basel)
July 2021
Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Benign so-called "brown tumors" secondary to hyperparathyroidism are a rare diagnostic pitfall due to their impressively malignant-like character in various imaging modalities. We present the case of a 65-year-old male patient with multiple unclear osteolytic lesions on prior imaging suspicious for metastatic malignant disease. Eventually, findings of F-FDG PET/CT staging and Tc-MIBI scintigraphy resulted in revision of the initially suspected malignant diagnosis.
View Article and Find Full Text PDFIntroduction: The incidence of parathyroid - glandula parathyreoideae (PTG) diseases has been increasing worldwide. Unlike benign tumours, the incidence of malignant PTG tumours is rather a rare diagnosis. The morbidity of parathyroid surgery is associated with surgical removal of one or more pathologically altered parathyroid glands, particularly parathyroid adenoma associated with primary hyperparathyroidism (HPPT), but also hyperplasia associated with secondary or tertiary HPPT, and last but not least, HPPT due to parathyroid cancer.
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