Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s1473-0502(01)00139-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Drug Development.
Alzheimers Dement
December 2024
Olabisi Onabanjo University, Sagamu, Ogun, Nigeria.
Background: Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid beta proteins to form plaques and the aggregation of hyperphosphorylated tau to form neurofibrillary tangles. Human fibroblast (SH-SY5Y) cells endogenously express Tau, and the expression is further amplified upon differentiation into neuronal cells, making it a cell model of Alzheimer's disease. Nigella sativa oil (NSO) contains 50% thymoquinone and has been used in the treatment of various nervous system disorders.
View Article and Find Full Text PDFDevelopment of a mertansine-specific DNA aptamer and novel high-throughput sandwich enzyme-linked oligonucleotide assay for quantification and characterization of trastuzumab emtansine.
Biosens Bioelectron
December 2024
Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address:
We developed a novel DNA aptamer, D8#24S1, which specifically recognizes mertansine (DM1), the cytotoxic payload of the antibody-drug conjugate (ADC) trastuzumab emtansine (T-DM1), and applied it for T-DM1 analysis. D8#24S1 was obtained through SELEX and was shown to specifically recognize DM1 with high affinity (dissociation constant, K = 84.2 nM).
View Article and Find Full Text PDFStudy of interaction in dual-species biofilm of Candida glabrata and Klebsiella pneumoniae co-isolated from peripheral venous catheter using Raman characterization mapping and machine learning algorithms.
Microb Pathog
January 2025
Laboratory of Catalysis and Synthesis in Organic Chemistry, University of Tlemcen, BP 119, Algeria.
Polymicrobial biofilm infections, especially associated with medical devices such as peripheral venous catheters, are challenging in clinical settings for treatment and management. In this study, we examined the mixed biofilm formed by Candida glabrata and Klebsiella pneumoniae, which were co-isolated from the same peripheral venous catheter. Our results revealed that C.
View Article and Find Full Text PDFA Toxicological and Ecotoxicological Assay Based on Mussel (Mytilus galloprovincialis) Hemocytes Motility.
J Vis Exp
December 2024
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento; NBFC, National Biodiversity Future Center;
Hemocytes are the circulating immune-competent cells in bivalve mollusks and play a key role in several important functions of cell-mediated innate immunity. During the early stages of the immune response, hemocytes actively migrate to the site of infection. This inherent motility is a fundamental characteristic of these cells.
View Article and Find Full Text PDFMultimodal nanoenzyme-linked aptamer assay for Salmonella typhimurium based on catalysis and photothermal effect of PB@Au.
Mikrochim Acta
January 2025
Shandong Provincial Key Laboratory of Animal Resistance Biology, Key Laboratory of Food Nutrition and Safety of Shandong, College of Life Science, Normal University, Shandong Normal University, Jinan, 250014, People's Republic of China.
A composite nanomaterial of Prussian blue@gold nanoparticles (PB@Au) with catalytic and photothermal properties was proposed, which combined with anti-matrix interference aptamers to achieve robust specificity and sensitivity in the detection of Salmonella typhimurium (S. typhimurium). The detection probe, PB@Au-Aptamer (PB@Au-Apt), was designed to exhibit high specificity for the target and catalyze the signal generation to produce a color change, thereby enabling rapid detection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!