Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Simultaneous separation and detection of common chiral and achiral metabolites in the urine of human exposed to benzene series by LC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
School of Ecology and Environment, Yuzhang Normal University, No.1999, Meiling Ave., Honggutan Dist., Nanchang 330103, Jiangxi, China.
Benzene, toluene, and xylene (BTX) are priority pollutants known for their hematotoxicity and carcinogenic properties. Benzene is further metabolized to phenyl mercapturic acid (PMA), toluene and xylene also generate benzyl mercapturic acid (BMA) in human urine. To confirm whether the exposure to benzene series comes from the workplace or from the external environment such as smoking is a very meaningful work, so accurate measurement of their biomarkers in biological samples is crucial.
View Article and Find Full Text PDFSafety of tartrazine in the food industry and potential protective factors.
Heliyon
September 2024
Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Article Synopsis
- Tartrazine, a food color, raises safety concerns due to its potential toxicity at low exposure levels, prompting more research since EFSA's 2009 and JECFA's 2016 evaluations.
- The review investigates various toxic effects of tartrazine, including genotoxicity, carcinogenicity, and effects on reproduction and blood health.
- Although tartrazine appears safe within the accepted daily intake, the evidence for protective factors against its toxic effects is not strong enough to make definitive conclusions.
Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol.
Biol Trace Elem Res
November 2024
Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.
3-chloro-1,2-propanediol (3-MCPD) is a member of the group of pollutants known as chloropropanols and is considered a genotoxic carcinogen. Due to the occurrence of 3-MCPD, which cannot be avoided in multiplexed food processes, it is necessary to explore novel agents to reduce or prevent the toxicity of 3-MCPD. Many recent studies on boron compounds reveal their superior biological roles such as antioxidant, anticancer, and antigenotoxic properties.
View Article and Find Full Text PDFExosomal derived miR-1246 from hydroquinone-transformed cells drives S phase accumulation arrest by targeting cyclin G2 in TK6 cells.
Chem Biol Interact
January 2024
The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China; Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address:
Background: Hydroquinone (HQ), a major metabolite of benzene and known hematotoxic carcinogen. MicroRNA 1246 (miR-1246), an oncogene, regulates target genes in carcinogenesis including leukemia. This study investigates the impact of exosomal derived miR-1246 from HQ-transformed (HQ19) cells on cell-to-cell communication in recipient TK6 cells.
View Article and Find Full Text PDFHydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Toxicol Lett
March 2023
Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Science, Ji'nan 250062, China. Electronic address:
Benzene is a frequent component of environmental pollution and is abundant in petrochemicals, decorative materials, motor vehicle exhaust and cigarette smoke. Benzene is a well-known carcinogen in humans and animals, but the molecular mechanism has not yet been elucidated. Our earlier research indicated that hydroquinone (HQ), one of the main reactive metabolites of benzene, could activate aryl hydrocarbon receptor (AhR), which is essential for HQ-induced toxicity, including apoptosis and DNA damage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!