This study tested for dissociations between age-related slowing in peripheral and central processes across semantic and episodic memory tasks. We report the mixed-model analysis of variance (ANOVA) results using reaction time (RT), error, and data from four different experimental tasks and eight data sets (the four tasks involved either multiple sessions or different stimuli) conducted on the same 80 participants (40 younger and 40 older adults). An earlier paper (Allen, Sliwinski, Bowie, & Madden, in press) reported the factor analysis and structural equation modeling results of this study. We employed two semantic memory tasks (lexical decision and multiplication verification) using data from two different sessions (for a total of four semantic data sets), and two episodic memory tasks (hybrid visual search and memory search with digits and with words as stimuli). For RT analyses, we found Age x Task interactions for all four episodic memory data sets, but no Age x Task interactions for the four semantic memory data sets. Also, the intercept (assumed to index peripheral processes) and slope (assumed to index central processes) analyses demonstrated that older adults (relative to younger adults) showed both intercept and slope decrements for episodic memory tasks, but only intercept decrements for semantic memory tasks. These data are consistent with a theoretical framework in which there are age-related dissociations between peripheral and central processes across semantic and episodic memory.
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http://dx.doi.org/10.1080/03610730252800157 | DOI Listing |
Neurology
February 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background And Objectives: Lipid metabolism in older adults is affected by various factors including biological aging, functional decline, reduced physiologic reserve, and nutrient intake. The dysregulation of lipid metabolism could adversely affect brain health. This study investigated the association between year-to-year intraindividual lipid variability and subsequent risk of cognitive decline and dementia in community-dwelling older adults.
View Article and Find Full Text PDFHum Brain Mapp
February 2025
Research Center for Social Computing and Information Retrieval, Harbin Institute of Technology, Harbin, China.
Pattern separation and pattern completion in the hippocampus play a critical role in episodic learning and memory. However, there is limited empirical evidence supporting the role of the hippocampal circuit in these processes during complex continuous experiences. In this study, we analyzed high-resolution fMRI data from the "Forrest Gump" open-access dataset (16 participants) using a sliding-window temporal autocorrelation approach to investigate whether the canonical hippocampal circuit (DG-CA3-CA1-SUB) shows evidence consistent with the occurrence of pattern separation or pattern completion during a naturalistic audio movie task.
View Article and Find Full Text PDFBMC Psychiatry
January 2025
School of Mental Health, Bengbu Medical University, Bengbu, Anhui, 233030, China.
Background: Although impaired cognitive control is common during the acute detoxification phase of substance use disorders (SUD) and is considered a major cause of relapse, it remains unclear after prolonged methadone maintenance treatment (MMT). The aim of the present study was to elucidate cognitive control in individuals with heroin use disorder (HUD) after prolonged MMT and its association with previous relapse.
Methods: A total of 63 HUD subjects (41 subjects with previous relapse and 22 non-relapse subjects, mean MMT duration: 12.
Neurobiol Aging
January 2025
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo 0317, Norway; Department of Radiology and Nuclear Medicine, University of Oslo, Oslo 0317, Norway.
Lower episodic memory capability, as seen in development and aging compared with younger adulthood, may partly depend on lower brain network segregation. Here, our objective was twofold: (1) test this hypothesis using within- and between-network functional connectivity (FC) during episodic memory encoding and retrieval, in two independent samples (n = 734, age 7-82 years). (2) Assess associations with age and the ability to predict memory comparing task-general FC and memory-modulated FC.
View Article and Find Full Text PDFGeroscience
January 2025
Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Background: Superagers, older adults with exceptional cognitive abilities, show preserved brain structure compared to typical older adults. We investigated whether superagers have biologically younger brains based on their structural integrity.
Methods: A cohort of 153 older adults (aged 61-93) was recruited, with 63 classified as superagers based on superior episodic memory and 90 as typical older adults, of whom 64 were followed up after two years.
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