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Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant -Induced Osteomyelitis.
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January 2025
Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van.
View Article and Find Full Text PDFStreptococcal Toxic Shock Syndrome (STSS) Secondary to Monoarticular Septic Arthritis Leading to Multiorgan Failure in a Patient without Underlying Comorbidities: Emphasizing Early Diagnosis and Management Strategies.
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HCA Healthcare Las Palmas/Del Sol Internal Medicine Program.
Background: Streptococcal Toxic Shock Syndrome (STSS) is a life-threatening condition caused by bacterial toxins. The STSS triad encompasses high fever, hypotensive shock, and a "sunburn-like" rash with desquamation. STSS, like Toxic Shock Syndrome (TSS), is a rare complication of streptococcal infec-tions caused by Group A Streptococcus (GAS), Streptococcal pyogenes (S.
View Article and Find Full Text PDFThe Potential Impacts of Single-use Plastic During the COVID-19 Pandemic.
Disaster Med Public Health Prep
January 2025
Department of Clinical Research, Northern Light Eastern Maine Medical Center, Bangor, ME, USA.
Objectives: Plastics in the environment have moved from an "eye-sore" to a public health threat. Hospitals are one of the biggest users of single-use plastics, and there is growing literature looking at not only plastics in the environment but health care's overall contribution to its growth.
Methods: This study was a retrospective review at a 411-bed level II trauma hospital over 47 months pre and post the last wave of COVID-19 affecting this hospital.
Clinical Outcomes of Discharged Patients With High Blood Pressure in the Emergency Department.
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Emergency Medicine, King Abdulaziz University Hospital, Jeddah, SAU.
Background: Elevated blood pressure (BP) prompts immediate emergency department (ED) visits instead of outpatient care, thus constituting a high-weight concern for the ED. This study investigated the short- and long-term outcomes of high BP patients in the ED.
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Extensive Arterial Dissection: A Rare Multivascular Emergency.
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Internal Medicine, Hospital de Braga, Braga, PRT.
Aortic dissection is a life-threatening vascular emergency associated with high morbidity and mortality. Clinical manifestations might include severe chest pain to neurological deficits, depending on the arterial segments involved. Extensive dissections involving multiple aortic segments and branch vessel occlusions, such as the carotid arteries, are rare and pose unique diagnostic and therapeutic challenges.
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