Paradoxically, the pituitary-adrenal axis is not activated during sodium lactate-induced panic. We measured the response of another stress-sensitive hormone, prolactin, to standard lactate and placebo infusion in a double-blind randomised design in eight patients with panic disorder and eight matched normal controls. Prolactin release was significantly elevated (P < 0.05) in panickers compared with non-panickers, whereas ACTH secretion was not activated at all. This differential stress response needs further investigation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0165-1781(02)00014-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation.
Cell Signal
December 2024
Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China. Electronic address:
Lactylation, a newly identified post-translational modification, is uncertain in its implication in triple-negative breast cancer (TNBC). In this study, we analyzed 60 TNBC samples using immunohistochemical staining and revealed elevated levels of pan-lactylated proteins and specific histone H4K12 lactylation in tumor tissues, correlating with TNBC progression. Lactate exposure in TNBC cell lines significantly induced lysine lactylation at the H4K12 site, leading to alterations in gene profiles and reduced apoptosis.
View Article and Find Full Text PDF7-amino carboxycoumarin 2 inhibits lactate induced epithelial-to-mesenchymal transition via MPC1 in oral and breast cancer cells.
Cell Biol Int
August 2024
Department of Medical Oncology (Lab), All India Institute of Medical Sciences, New Delhi, India.
Lactate is an oncometabolite that play important role in tumor aggressiveness. Lactate from the tumor microenvironment (TME) is taken up by cancer cells as an energy resource via mitochondrial oxidative phosphorylation (or OXPHOS). In the present study, by using an online meta-analysis tool we demonstrated that in oral squamous cancer cells (OSCCs) glycolytic and OXPHOS governing genes are overexpressed, like in breast cancer.
View Article and Find Full Text PDFLactate-induced mtDNA Accumulation Activates cGAS-STING Signaling and the Inflammatory Response in Sjögren's Syndrome.
Int J Med Sci
October 2023
Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- The study investigates acinar epithelial cell atrophy in primary Sjögren's syndrome (pSS), focusing on how the high-lactate environment in salivary glands affects cellular metabolism and mitochondrial function.
- Researchers identified that salivary gland epithelial cells showed elevated levels of inflammatory cytokines and activated specific pathways related to inflammation when exposed to high lactate levels.
- The findings suggest that lactate damages mitochondrial DNA, leading to inflammation, but this response can be mitigated by using sodium dichloroacetate (DCA), offering new perspectives on treating pSS.
Buyang Huanwu Decoction: A Traditional Chinese Medicine, Promotes Lactate-Induced Angiogenesis in Experimental Intracerebral Hemorrhage.
Evid Based Complement Alternat Med
October 2022
Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Identifying the underlying mechanisms and exploring effective therapies for intracerebral hemorrhage (ICH) are urgently needed. Here, we aim to elucidate the potential roles and underlying mechanisms of Buyang Huanwu decoction (BYHWD) in ICH. In the first set of experiments, rats were randomly divided into five groups: Sham, ICH, ICH + sodium oxamate (OXA), ICH + BYHWD, and ICH + BYHWD + OXA.
View Article and Find Full Text PDFLactate-induced lactylation in skeletal muscle is associated with insulin resistance in humans.
Front Physiol
August 2022
Department of Biomedical Sciences, Ohio University, Athens, OH, United States.
Elevated circulating lactate has been associated with obesity and insulin resistance. The aim of the current study was to determine if lactate-induced lysine lactylation (kla), a post-translational modification, was present in human skeletal muscle and related to insulin resistance. Fifteen lean (Body Mass Index: 22.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!