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Vanishing twins, selection , and infant mortality in the United States.
Evol Med Public Health
January 2025
Department of Health, Society, and Behavior, Joe C. Wen School of Population and Public Health, University of California, Irvine, CA, USA.
Background And Objectives: Research to identify fetal predictors of infant mortality among singletons born in the United States (US) concludes that poorly understood and unmeasured "confounders" produce a spurious association between fetal size and infant death. We argue that these confounders include Vanishing Twin Syndrome (VTS)-the clinical manifestation of selection against frail male twins . We test our argument in 276 monthly conception cohorts conceived in the US from January 1995 through December 2017.
View Article and Find Full Text PDFBiodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate.
Biomed Hub
December 2024
Departments of Surgery, Yale School of Medicine, New Haven, CT, USA.
Introduction: Monogenic diseases can be diagnosed before birth. Systemic fetal administration of nanoparticles (NPs) grants therapeutic access to developing stem cell populations impacted by these classes of disease. Delivery of editing reagents in these NPs administered before birth has yielded encouraging results in preclinical mouse models of monogenic diseases.
View Article and Find Full Text PDFPregnancy and Postpartum Effects of Electronic Cigarettes on Maternal Health and Vascular Function in the Fourth Trimester.
Cardiovasc Toxicol
January 2025
Department of Physiology, Pharmacology and Toxicology, West Virginia University School of Medicine, Morgantown, WV, USA.
Pregnancy is a vulnerable time with significant cardiovascular changes that can lead to adverse outcomes, which can extend into the postpartum window. Exposure to emissions from electronic cigarettes (Ecig), commonly known as "vaping," has an adverse impact on cardiovascular function during pregnancy and post-natal life of offspring, but the postpartum effects on maternal health are poorly understood. We used a Sprague Dawley rat model, where pregnant dams are exposed to Ecigs between gestational day (GD)2-GD21 to examine postpartum consequences.
View Article and Find Full Text PDFPerinatal outcomes and predictors of placental abruption: a retrospective study in an Ethiopian tertiary care center.
Front Public Health
January 2025
Department of Epidemiology, St. Peter Specialized Hospital, Addis Ababa, Ethiopia.
Background: Placental abruption is a critical obstetric condition characterized by the premature separation of the placenta from the uterus, leading to severe maternal and fetal complications. In Ethiopia, the maternal and perinatal morbidity and mortality rates are alarmingly high, and placental abruption significantly contributes to these adverse outcomes. Despite its severity, there is a lack of comprehensive data on the burden, risk factors, and outcomes associated with placental abruption in the Ethiopian context.
View Article and Find Full Text PDF[Reducing the Invalid Alarm Rate for Fetal Heartbeat Monitoring in High-Risk Pregnancies in the Delivery Room].
Hu Li Za Zhi
February 2025
Department of Nursing, National Taiwan University Hospital, Taiwan, ROC.
Background & Problems: Fetal heartbeat (FHB) monitoring is used to monitor the condition of a fetus in the uterus and estimate the expected time of delivery. It is crucial to accurately and comprehensively monitor fetal heart beats in high-risk pregnancies. However, invalid alarms frequently occur in clinical environments, easily promoting alarm fatigue among nurses and causing anxiety and distrust in the laboring women and their families.
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