Objective: To assess whether obesity and/or gestational diabetes mellitus (GDM) are independent risk factors for fetal macrosomia and/or pregnancy-induced hypertensive disorders.
Design: Retrospective computerised database review.
Setting: Lyell McEwin Health Service, South Australia.
Sample: All nulliparous women delivering singleton babies in the years 1999 and 2000
Main Outcome Measures: Birth weights, the occurrence of fetal macrosomia, gestational hypertension and preeclampsia were compared between 258 normoglycaemic women (control group), 76 women with only an abnormal glucose challenge test, and 51 women with GDM.
Results: Only GDM with fasting hyperglycaemia is a risk factor for macrosomia (risk ratio: 3.3 95% confidence limits 1.229-8.736). Smoking is associated with a decrease in the incidence of pregnancy-induced hypertensive disorders.
Conclusions: Our data strongly suggest that GDM and obesity are not independent risk factors for pregnancy-induced hypertensive disorders.
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http://dx.doi.org/10.1111/j.0004-8666.2002.00035.x | DOI Listing |
Bioelectrochemistry
January 2025
Tongzhou Maternal & Child Health Hospital of Beijing, No. 124, Yuqiao Middle Road, Tongzhou District, Beijing 101101 PR China. Electronic address:
Cystatin C (Cys-C) is emerging as a critical biomarker for assess gestational diabetes mellitus (GDM), a condition that significantly impacts maternal and fetal health. In this study, we developed a novel label-free electrochemical immunosensor designed for point-of-care applications, offering lower reagent consumption and rapid detection of Cys-C in pregnant women with GDM. Compared to traditional enzyme-linked immunosorbent assays (ELISA), the sensor demonstrates enhanced sensitivity, reduced reagent usage, and faster detection.
View Article and Find Full Text PDFCirc Res
January 2025
Department of Medicine, Division of Clinical Pharmacology; and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (M.R.A.).
Background: Cardiovascular diseases are the primary cause of nonobstetric morbidity and mortality in pregnant women worldwide. Pakistan's high maternal and neonatal mortality rates underscore the need for effective screening protocols to detect cardiovascular diseases during pregnancy.
Objectives: The objective of this study was to assess the prevalence and factors associated with structural heart disease among pregnant women without active cardiorespiratory symptoms (no symptoms or symptoms attributed to pregnancy) attending routine antenatal appointments.
PLoS One
January 2025
Duke Center for Policy Impact in Global Health, Durham, North Carolina, United States of America.
Background: Hypertension is the most common primary diagnosis associated with postpartum readmissions within 42 days of delivery hospitalization. In the United States, nearly half of the cases of eclampsia, a severe form of preeclampsia, develop during the postpartum period, and the postpartum onset of hypertensive disorders of pregnancy, like antepartum hypertension poses long-term health risks to pregnant individuals, including an increased likelihood of developing overall cardiovascular disease, coronary heart disease, heart failure, and chronic hypertension. In this paper, we estimate the trends in the incidence of readmissions for postpartum hypertension within 42 days of delivery discharge in the US, disaggregated by median household income.
View Article and Find Full Text PDFBMJ Open
December 2024
Department of Obstetrics, University Medical Centre Utrecht, Utrecht, The Netherlands
Objective: In the puerperium, women with hypertensive disease of pregnancy remain at risk for maternal complications. The antihypertensive agent prescribed antepartum is usually continued postpartum; however, evidence regarding the most effective treatment is lacking. Therefore, we aimed to investigate which antihypertensive agent results in optimal treatment (both effectiveness and safety) of postpartum hypertension.
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