Hypertension, hyperinsulinaemia and dyslipidaemia are strong and independent risk factors for cardiovascular diseases. Their increasing frequency in postmenopausal women suggests that oestrogen deficiency may be a contributing factor. It is well known that oestrogen replacement therapy in postmenopausal women improves carbohydrate and lipid metabolism, but the effect of combined hormone replacement therapy (HRT) remains unclear. The purpose of the present study was to evaluate the effect of HRT on blood pressure, carbohydrate metabolism and lipid profile in postmenopausal women with primary arterial hypertension. The study population consisted of 76 postmenopausal women (mean age 51.1 +/- 6.8 years). Forty hypertensive women received HRT (17-beta-oestradiol, norethisterone acetate, TTS, Estracomb Novartis), whereas 36 women remained without hormonal therapy. One-year combined transdermal HRT did not affect significantly blood pressure and blood pressure variability. HRT was shown to improve lipid profile with a significant decrease in total cholesterol as early as at 3 months. It does not influence carbohydrate metabolism parameters studied by glycaemia and insulinaemia in a standard oral glucose tolerance test. In conclusion, combined percutaneous HRT may reduce the lipid-depended cardiovascular risk in postmenopausal women with arterial hypertension.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/080370502753543936 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Type 2 diabetes patients exhibit delayed but coupled bone remodelling, maintaining cortical porosity comparable to healthy controls: A histomorphometric analysis of trans-iliac bone biopsies.
Bone
January 2025
Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, DK-5000 Odense C, Denmark; Steno Diabetes Centre Odense, Odense University Hospital, DK-5000 Odense C, Denmark.
Objective: Fracture risk is increased in longstanding type 2 diabetes (T2D). High-resolution peripheral quantitative CT scans have demonstrated higher cortical porosity in T2D complicated by microvascular disease (MVD). We investigated if cortical bone resorption is followed by inadequate bone formation in individuals with T2D complicated by MVD.
View Article and Find Full Text PDFAssociation between menopausal age and smoking status defined using urinary cotinine or tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol: The Korea National Health and Nutrition Examination Survey 2016-2018.
Reprod Toxicol
January 2025
Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
This study aimed to establish the optimal cut-off values for urinary cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)to determine smoking status in Korean women over 20 years of age and to assess the correlation of these biomarkers with reproductive health, particularly menopausal age, in postmenopausal women. Utilizing data from the 7th edition of the Korea National Health and Nutrition Examination Survey (2016- 2018), researchers included postmenopausal women aged 40-60 years who were within 5 years of menopause. Self-reported smoking status was aligned with biomarkers levels to calculate optimal cut-off values, classifying a total of 503 postmenopausal women into four groups: never smokers (cotinine <0.
View Article and Find Full Text PDFLongitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study.
BMC Pulm Med
January 2025
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background/aims: Evidence regarding the long-term association between hemoglobin (Hb) levels and lung function in individuals from the general population is scarce. This study aimed to determine the longitudinal association between Hb levels and lung function in a community-based population cohort in South Korea.
Methods: We used linear mixed regression analysis to evaluate the longitudinal associations between Hb levels and lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), and FEV/FVC.
Impact of Early Menopause and Hormonal Therapy Replacement on Aortic Stenosis Progression.
Can J Cardiol
January 2025
Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec city, Québec, Canada. Electronic address:
Background: Early menopause has been associated with several cardiovascular diseases. Its impact on the progression of aortic stenosis (AS) remains unknown. We conducted an analysis to examine the impact of early menopause without hormonal replacement therapy (HRT) on the progression of AS in postmenopausal women with AS.
View Article and Find Full Text PDFClinical Hypnosis and Cognitive Behavioral Therapy for Hot Flashes: A Scoping Review.
Womens Health Rep (New Rochelle)
January 2025
Department of Psychology & Neuroscience, Baylor University, Waco, Texas, USA.
Background: Hot flashes can be a prevalent issue for postmenopausal women, but traditional treatments such as hormone therapy can have adverse side effects. Recommended psychotherapies for managing hot flashes include cognitive behavioral therapy (CBT) and clinical hypnosis, but an in-depth review comparing the efficacy of both treatments is warranted.
Objectives: The aim of the present scoping review was to assess the clinical significance and efficacy of symptom reduction of CBT and clinical hypnosis as treatments of hot flashes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!