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Design and Process Considerations for Preparation of Modified Release Ivermectin and Praziquantel Tablets by Wet Granulation.
AAPS PharmSciTech
January 2025
University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, 20 N Pine Street, Baltimore, Maryland, 21201, USA.
Dosage forms containing Ivermectin (IVER) and Praziquantel (PRAZ) are important combination drug products in animal health. Understanding the relationship between products with differing in vitro release characteristics and bioequivalence could facilitate generics. The goal of this study was to create granulations for each active ingredient, with similar release mechanisms, but substantially different in vitro release rates, and then compressing these granulations into tablets with differing release rates.
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BMC Genomics
January 2025
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
The E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. The present study involves whole-genome-wide comparison and phylogenetic analysis of pks harboring E.
View Article and Find Full Text PDF[Examination of Capsule Genotypes, Antibiotic Susceptibility Profiles and Biofilm Forming Abilities of Group B Streptococcus Isolates Isolated from Pregnant Women].
Mikrobiyol Bul
October 2024
Çukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Türkiye.
Group B Streptococcus (GBS) or Streptococcus agalactiae is a pathogen that causes infections during pregnancy. The aim of this study was to investigate the antibiotic sensitivity profiles, capsule genotypes and biofilm forming capabilities of GBS isolates obtained from pregnant women . The study included 252 pregnant women who applied to Adana Gynecology and Children's Hospital between 2018 and 2023.
View Article and Find Full Text PDFresistance in Hainan Province, China: investigating phenotypes and genotypes through whole-genome sequencing.
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Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
is increasingly resistant to antibiotics, significantly lowering eradication rates and posing a major public health challenge. This study investigated the distribution of antibiotic-resistant phenotypes and genotypes of in Hainan Province. It determined the minimum inhibitory concentrations (MICs) of six antibiotics using the E-test method and detected resistance genes via Sanger sequencing.
View Article and Find Full Text PDFAntifungal susceptibility profile of Candida species and uncommon yeasts from drug abusers with oral candidiasis.
BMC Oral Health
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Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
In Iran, there is limited information regarding the species distribution and antifungal susceptibility profiles of yeast isolates from drug addicts suffering from oral candidiasis (OC). In this study, 104 yeast isolates, including 98 Candida species and 6 uncommon yeasts, were collected from 71 drug abusers with OC. The susceptibility profiles of Candida spp.
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