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(Pers.) C.D. Adams and Crantz Exhibit Antibacterial Activity against Resistant Strains.
Scientifica (Cairo)
August 2024
Department of Pharmaceutics Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Typhoid fever, caused by , has plagued underdeveloped countries for many years. Recently, there has been a surge in strains identified to be multidrug-resistant in endemic areas. and have been reported to exhibit activity against ; however, this study aimed to investigate the effect of and against resistance strains of The leaves of the plants were extracted using distilled water (hot (A) and cold (A)), methanol (M), ethyl acetate, and petroleum ether.
View Article and Find Full Text PDFUncovering the growing burden of enteric fever: A molecular analysis of Salmonella Typhi antimicrobial resistance.
Microb Pathog
June 2024
University Institute of Medical Laboratory Technology, Faculty of Allied Health Sciences, The University of Lahore, Pakistan; Department of Microbiology, Faculty of Science, Emerson University Multan, Pakistan. Electronic address:
Enteric fever, a persistent public health challenge in developing regions, is exacerbated by suboptimal socioeconomic conditions, contaminated water and food sources, and insufficient sanitation. This study delves into the antimicrobial susceptibility of Salmonella Typhi, uncovering the genetic underpinnings of its resistance. Analyzing 897 suspected cases, we identified a significant prevalence of typhoid fever, predominantly in males (58.
View Article and Find Full Text PDFPredominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.
PLoS Negl Trop Dis
April 2024
Department of Clinical Science, University of Medicine, Bergen, Norway.
Background: Typhoid fever is a common cause of febrile illness in low- and middle-income countries. While multidrug-resistant (MDR) Salmonella Typhi (S. Typhi) has spread globally, fluoroquinolone resistance has mainly affected Asia.
View Article and Find Full Text PDFGlobal diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Typhi genomes.
Elife
September 2023
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Background: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000).
Methods: This is a meta-analysis of global genotype and antimicrobial resistance (AMR) determinants extracted from previously sequenced genome data and analysed using consistent methods implemented in open analysis platforms GenoTyphi and Pathogenwatch.
Antimicrobial susceptibility pattern and genotypic characterisation of quinolone and ceftriaxone resistant genes among Salmonella typhi from various regions of Pakistan.
J Pak Med Assoc
November 2022
Department of Pathology, Armed Forces Institute of Pathology, Rawalpindi,Pakistan.
Objective: To determine the current antibiotic resistance patterns and identification of quinolone and ceftriaxone resistant genes among Salmonella enterica subspecies serovar Typhi.
Methods: The prospective study was conducted from September 2018 to March 2019 and comprised samples collected from major hospitals and laboratories in Karachi, Quetta, Lahore, Kharia, Rawalpindi, Islamabad and Peshawar after approval from the institutional ethics review board of Hazara University, Mansehra, Pakistan. Antimicrobial susceptibility of isolates collected from the health facilities was checked using the Kirby Bauer disc diffusion method in line with the Clinical and Laboratory Standards Institute guidelines at the Department of Microbiology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.
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